On the future of mass‐spectrometry‐based lipidomics

Abstract

Lipids have highly diverse functions that go beyond cellular membrane structure and energy storage. One of the great challenges in lipid research will be to understand how the enormous complexity of lipid homeostasis is maintained. Genetic approaches combined with mass spectrometry-based lipidomics will help to elucidate how cells create and maintain their nonrandom lipid distribution within tissues, cells, organelles and lipid bilayers. Lipid homeostasis is crucial for many cellular processes and we are currently only beginning to understand the specific functions of lipids and the local environment that they create.

A MALDI-MSI Approach to the Characterization of Radiation-Induced Lung Injury and Medical Countermeasure Development

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“…cancer diagnosis and obesity research [117][118][119] . Methods in lipidomics have centered around mass spectrometry over the recent years 120 . Besides global, quantifying methods such as GC-MS, MSI has rapidly taken over a predominant role in Lipidomics.…”

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