On the Future of Information: Reunification, Computability, Adaptation, Cybersecurity, Semantics

Pissanetzky, Sergio

doi:10.1109/access.2016.2524403

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…Changes in functional expression of P2X 3 receptors are closely related to inflammation, while CFA injections or chronic nerve compression and temporal mandibular joint disorders increase the expression of P2X 3 receptors ( Xu and Huang, 2002 ; Ambalavanar et al, 2005 ; Shinoda et al, 2005 ). Intrathecal injection of P2X 3 receptor agonist α, β -meATP enhances pain behavior ( Xiang et al, 2008 ), while intrathecal injection of P2X 3 receptor antagonist A-317491 or treatment with antisense P2X 3 receptor oligonucleotides significantly reduces formalin- or α, β -meATP injection-induced nociceptive behavior and nociceptive inflammatory response in DRG and spinal cord after partial sciatic nerve ligation, CFA adjuvant, formalin or α, β -meATP injection into the skin ( Barclay et al, 2002 ; Hemmings-Mieszczak et al, 2003 ; McGaraughty et al, 2003 ; Pissanetzky, 2016 ). In addition, inflammatory cytokines IL-1, IL-6, and TNF-α also contribute to the pathophysiology of chronic pain ( del Rey et al, 2012 ; Li et al, 2017 ; Yang et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Polyphyllin VI screened from Chonglou by cell membrane immobilized chromatography relieves inflammatory pain by inhibiting inflammation and normalizing the expression of P2X3 purinoceptor

et al. 2023

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Objective: Inflammatory pain is one of the most common diseases in daily life and clinic. In this work, we analysed bioactive components of the traditional Chinese medicine Chonglou and studied mechanisms of their analgesic effects.Material and methods: Molecular docking technology and U373 cells overexpressing P2X3 receptors combined with the cell membrane immobilized chromatography were used to screen possible CL bioactive molecules interacting with the P2X3 receptor. Moreover, we investigated the analgesic and anti-inflammatory effects of Polyphyllin VI (PPIV), in mice with chronic neuroinflammatory pain induced by CFA (complete Freund’s adjuvant).Results: The results of cell membrane immobilized chromatography and molecular docking showed that PPVI was one of the effective compounds of Chonglou. In mice with CFA-induced chronic neuroinflammatory pain, PPVI decreased the thermal paw withdrawal latency and mechanical paw withdrawal threshold and diminished foot edema. Additionally, in mice with CFA-induced chronic neuroinflammatory pain, PPIV reduced the expression of the pro-inflammatory factors IL-1, IL-6, TNF-α, and downregulated the expression of P2X3 receptors in the dorsal root ganglion and spinal cord.Conclusion: Our work identifies PPVI as a potential analgesic component in the Chonglou extract. We demonstrated that PPVI reduces pain by inhibiting inflammation and normalizing P2X3 receptor expression in the dorsal root ganglion and spinal cord.

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Section: Discussionmentioning

confidence: 99%

Polyphyllin VI screened from Chonglou by cell membrane immobilized chromatography relieves inflammatory pain by inhibiting inflammation and normalizing the expression of P2X3 purinoceptor

et al. 2023

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“…They verify published cybergraphic which can significantly hide data sharing [18]. This article focused on the vulnerability of software and the internet and the accumulation of raw information in big data, which are serious problems in computing [19]. The authors proposed the technological capacity they have to mitigate internal threats in computer security systems, with a systematic review of mixed methods [20].…”

Section: Related Jobsmentioning

confidence: 99%

Prototype to Mitigate the Risks, Vulnerabilities and Threats of Information to Ensure Data Integrity

Toapanta¹,

Durango²,

Gallegos³

et al. 2022

Adv. sci. technol. eng. syst. j.

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The constant evolution of Information and Communication Technologies, Internet, access to different free software, among others; they generate problems in the management of information security in companies; to mitigate risks, vulnerabilities, and information threats, an alternative was presented considering that information security systems are the basis for decision-making at the government, strategic, tactical, and operational levels. The objective is to design a security prototype applied to business management to mitigate risks, vulnerabilities and threats to information. The deductive method and exploratory research were used for the analysis of the information. Turned out prototypes that allow mitigating risks, vulnerabilities and threats in information management for data control and integrity. It was concluded that the security prototype proposed for a commercial information system; it is security system suitable for public and private companies. In the simulation carried out, it was determined that if the number of risks and threats is high, there will be a greater probability that a problem will arise in the security of the system.

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“…The proposed solutions are based on more human interventions, which tend to exacerbate rather than solve the problems. In both cases, the study [38] propose the complete elimination of human interventions. This goal is easy to achieve conceptually.…”

Section: Software Defined Network Attacks and Aimentioning

confidence: 99%

The future of Artificial Intelligence in Cybersecurity: A Comprehensive Survey

Tao¹,

Akhtar²,

Zhang³

2021

EAI Endorsed Transactions on Creative Technologies

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AI in Cybersecurity Market scheme helps organizations in observance, detecting, reporting, and countering cyber threats to keep up information confidentiality. The increasing awareness among folks, advancements in info technology, up-gradation of intelligence and police work solutions, and increasing volume of knowledge gathered from numerous sources have demanded the utilization of reliable and improved cybersecurity solutions all told industries. The increase in the incidence and quality of cyber-attacks is driving AI-enabled cyber systems. Increasing incidents of huge cyber-attacks globally have created awareness among organizations for securing their information. The motive behind these cyber-criminals are political competition, competitors move for gain and harming the name of others, international information theft, and radical nonsecular cluster interest. Most cyber-attacks are for gain. In this review we have presented some previous studies related to Cybersecurity which involves AI.

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On the Future of Information: Reunification, Computability, Adaptation, Cybersecurity, Semantics

Cited by 5 publications

References 25 publications

Polyphyllin VI screened from Chonglou by cell membrane immobilized chromatography relieves inflammatory pain by inhibiting inflammation and normalizing the expression of P2X3 purinoceptor

Polyphyllin VI screened from Chonglou by cell membrane immobilized chromatography relieves inflammatory pain by inhibiting inflammation and normalizing the expression of P2X3 purinoceptor

Prototype to Mitigate the Risks, Vulnerabilities and Threats of Information to Ensure Data Integrity

The future of Artificial Intelligence in Cybersecurity: A Comprehensive Survey

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