Let S be an unramified regular local ring of mixed characteristic two and R the integral closure of S in a biquadratic extension of its quotient field obtained by adjoining roots of sufficiently general square free elements f, g ∈ S. Let S 2 denote the subring of S obtained by lifting to S the image of the Frobenius map on S/2S. When at least one of f, g ∈ S 2 , we characterize the Cohen Macaulayness of R and show that R admits a birational small Cohen Macaulay module. It is noted that R is not automatically Cohen Macaulay in case f, g ∈ S 2 or if f, g / ∈ S 2 .