On the etiology of vitiligo and gray hair

Lerner, Aaron B.

doi:10.1016/0002-9343(71)90232-4

Cited by 287 publications

(156 citation statements)

References 23 publications

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“…V itiligo is a cutaneous pigmentary disorder that affects approximately 1% of the world population (Lerner, 1971). It is characterized by milk-white macules of the skin and complete disappearance of melanocytes at the lesional site (Le Poole et al, 1993b).…”

mentioning

confidence: 99%

Local Immune Response in Skin of Generalized Vitiligo Patients

Wijngaard

Wańkowicz-Kalińska

Poole

et al. 2000

Laboratory Investigation

218

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SUMMARY:In situ immune infiltrates in lesional, perilesional, and nonlesional skin biopsies from patients with vitiligo were analyzed by immunohistochemistry and compared with immune infiltrates found in the skin of normal healthy donors and relevant disease controls. An increased influx of activated skin-homing T cells and macrophages were seen in the perilesional biopsies. The overall percentages of cutaneous leukocyte-associated antigen-positive (CLA ϩ ) T cells were similar to those found in normal healthy donors. This is compatible with the similar expression of E-selectin. Most strikingly, however, the CLA ϩ T cells in perilesional skin were mainly clustered in the vicinity of disappearing melanocytes, and 60% to 66% of these interacting T cells expressed perforin and granzyme-B. The perforin ϩ /granzyme-B ϩ cells were not seen in locations different from that of disappearing melanocytes. Interestingly, the majority of the infiltrating T cells were HLA-DR/CD8 ϩ . Another hallmark of the present study is the focal expression of intercellular adhesion molecule (ICAM)-1 and HLA-DR in the epidermis at the site of interaction between the immune infiltrates and the disappearing melanocytes. The data presented in this study are consistent with a major role for skin-homing T cells in the death of melanocytes seen in vitiligo. (Lab Invest 2000, 80:1299-1309.

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mentioning

confidence: 99%

Local Immune Response in Skin of Generalized Vitiligo Patients

Wijngaard

Wańkowicz-Kalińska

Poole

et al. 2000

Laboratory Investigation

218

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“…It is estimated to occur in up to 2% of the world's population 16 . The incidence of the disease is higher in those with racially pigmented skin, where the social and psychological impact is also greater.…”

Section: Vitiligomentioning

confidence: 99%

Disorders of Pigmentation of the Skin - Hypotheses Underlying Interventions by Multiple Systems of Medicine:Is there a Role for Integrated Medicine?

Arianayagam

Ryan

2016

Current Science

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Biomedicine has not provided a complete explanation with fully effective therapies for disorders of pigmentation. Biomedicine emphasizes the role of melanocyte for protection from UV rays and as a determinant of skin colour. These important properties acquired a genetic basis much later than other functions, many relating to cell contact as in the keratinocyte -melanocyte unit, or as with the synapses of the neurological system. There are other roles, biochemical and mechanical, of melanocyte. Management that is inclusive of a maximally holistic approach justifies the use of diverse herbals, yoga and concern for cultural awareness provided by integrated medicine. Vitiligo provides a model which demonstrates that Ayurveda has a richer view of its presentations, possibly a stronger line on its pathogenesis, and a huge range of herbals, many now backed by studies from ethnobotanical laboratories, awaiting research into the many possible mechanisms by which they may act in the wide and complex field of melanocyte biochemistry.

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“…Three etiological hypotheses stand out: the neurogenic, the autodestructive and the immunological hypotheses. 1,2 Although etiological and pathological factors may work separately or together, the immunological hypothesis is the one providing the most consistent clinical and experimental evidences. In halo nevus, the antigenicity of melanocytes is strongly suggested by presence of a lymphocytic infiltrate, spontaneous regression of the pigmented area, with destruction of nevus cells and perinevic melanocytes leading to an achromic halo, and by the occasional presence of leucoderma in malignant melanoma.…”

Section: Introductionmentioning

confidence: 99%

Estudo comparativo entre vitiligo, nevo halo e lúpus eritematoso vitiligóide por meio de métodos imunológicos, histológicos e imuno-histoquímicos

Filho

Rivitti

Miyauchi

et al. 2005

An. Bras. Dermatol.

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The results confirm the existence of antimelanocyte antibodies in vitiligo and halo nevus. It is not possible to rule out some immunological phenomena similar to those occurring in vitiligo and halo nevus in the genesis of vitiligoid lesions in lupus erythematous. The detection of melanocytes in achromic lesions of vitiligo suggests the predominance of a functional inhibitory mechanism rather than cell destruction in the genesis of the disease. Keywords: Allergy and Immunology; Lupus; Nevus, Pigmented; Vitiligo. Resumo: FUNDAMENTOS: O estudo compara o vitiligo, o nevo halo (NH) e lúpus eritematoso vitiligóide (LEV) do ponto de vista imunológico, histológico e histoquímico. OBJETIVOS: Avaliar diferenças imuno-histoquímicas entre essas doenças e investigar se a despigmentação do LEV deve-se à destruição pós-infla-

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On the etiology of vitiligo and gray hair

Cited by 287 publications

References 23 publications

Local Immune Response in Skin of Generalized Vitiligo Patients

Local Immune Response in Skin of Generalized Vitiligo Patients

Disorders of Pigmentation of the Skin - Hypotheses Underlying Interventions by Multiple Systems of Medicine:Is there a Role for Integrated Medicine?

Estudo comparativo entre vitiligo, nevo halo e lúpus eritematoso vitiligóide por meio de métodos imunológicos, histológicos e imuno-histoquímicos

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