A polynomial is called self-reciprocal (or palindromic) if the sequence of its coefficients is palindromic. In this paper we enumerate self-reciprocal irreducible monic polynomials over a finite field with prescribed leading coefficients. Asymptotic expression with explicit error bound is derived, which is used to show that such polynomials with degree 2n always exist provided that the number of prescribed leading coefficients is slightly less than n/4. Exact expressions are also obtained for fields with two or three elements and up to two prescribed leading coefficients.