The primary aims of this report are to provide a review of current literature pertaining to fitness and healthrelated outcomes following spinal cord injury (SCI), to identify the common and relevant fitness assessment techniques, to describe key evidence-based intervention strategies for improving health-related components of fitness among persons with SCI and to identify emerging and future trends in health-related fitness programming for rehabilitation and research. SCI results in a partial or total loss of neural signal transmission at and below the level of injury, characterized by motor and sensory loss. About 250,000-400,000 individuals have a SCI in the USA with approximately 12,000 new injuries occurring annually. The loss of somatic and autonomic control results in a reduction of physical activity and blunted cardiovascular response to exercise. The consequences of this reduction in physical activity are significant physical deconditioning, altered body composition, and development of detrimental metabolic profiles leading to poorer health outcomes in this population. Over the past decade, much attention has been devoted to understanding the relationship between exercise participation, physical activity, and physical fitness and their impact on health-related outcomes following SCI. Physical fitness interventions are of great importance to the SCI consumer and clinicians whose goals are to halt the deconditioning process, increase functional capacity, and decrease secondary health complications associated with chronic SCI. Exercise risk evaluation and individualized fitness assessments for body composition, muscular strength/endurance, and cardiorespiratory fitness should precede implementation of exercise interventions. Current evidence indicates that both electrically stimulated and volitional exercise strategies have the potential to improve components of fitness, reduce the risk of secondary health complications, and positively impact overall health for those with chronic physical disability. However, given the complexity of SCI with respect to level and severity of injury, a clear consensus on the optimal frequency, duration, and intensity of exercise needed to ensure lasting effects on health-related outcomes has yet to be determined. In addition, as is the case in non-injured populations, consideration should be given to both diet and exercise, not exercise alone, when considering the optimal strategy for improving body composition and cardiovascular health for persons with SCI.