On the effect of marrow in the mechanical behavior and crush response of trabecular bone

Halgrin, Julien; Chaari, Fahmi; Markiewicz, Éric

doi:10.1016/j.jmbbm.2011.09.003

Cited by 21 publications

(32 citation statements)

References 15 publications

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“…However, loading pressures in vivo, while performing normal activities (standing up or climbing stairs) have been found to be as high as 18 MPa (37). This supports the idea that there is an important in vivo component added to the function of trabeculae as scaffolding, and is the presence of bone marrow within the bone, mainly fatty marrow (38).…”

Section: Mechanical Implicationssupporting

confidence: 80%

Fat and bone: the multiperspective analysis of a close relationship

Gómez¹,

Benavent²,

Simoni³

et al. 2020

Quant Imaging Med Surg

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The study of bone has for many years been focused on the study of its mineralized component, and one of the main objects of study as radiology developed as a medical specialty. The assessment has until recently been almost limited to its role as principal component of the scaffolding of the human body. Bone is a very active tissue, in continuous cross-talk with other organs and systems, with functions that are endocrine and paracrine and that have an important involvement in metabolism, ageing and health in general. Bone is also the continent for the bone marrow, in the form of "yellow marrow" (mainly adipocytes) or "red marrow" (hematopoietic cells and adipocytes). Recently, numerous studies have focused on these adipocytes contained in the bone marrow, often referred to as marrow adipose tissue (MAT). Bone marrow adipocytes do not only work as storage tissue, but are also endocrine and paracrine cells, with the potential to contribute to local bone homeostasis and systemic metabolism. Many metabolic disorders (osteoporosis, obesity, diabetes) have a complex and still not well-established relationship with MAT. The development of imaging methods, in particular the development of cross-sectional imaging has helped us to understand how much more laid beyond our classical way to look at bone. The impact on the mineralized component of bone in some cases (e.g., osteoporosis) is well-established, and has been extensively analyzed and quantified through different radiological methods. The application of advanced magnetic resonance techniques has unlocked the possibility to access the detailed study, characterization and quantification of the bone marrow components in a non-invasive way. In this review, we will address what is the evidence on the physiological role of MAT in normal skeletal health (interaction with the other bone components), during the process of normal aging and in the context of some metabolic disorders, highlighting the role that imaging methods play in helping with quantification and diagnosis.

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Section: Mechanical Implicationssupporting

confidence: 80%

Fat and bone: the multiperspective analysis of a close relationship

Gómez¹,

Benavent²,

Simoni³

et al. 2020

Quant Imaging Med Surg

View full text Add to dashboard Cite

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“…Additionally, the increase in Young's modulus seen after the removal of marrow is similar to that documented by Halgrin et al . (), who concluded that the marrow had caused increased transverse pressure and local stress on trabeculae, leading to its premature failure. Our results would also suggest that the material was not demineralized by the wash process, as this would have compromised the biomechanical stability of the bone (Chen and McKittrick, ).…”

Section: Discussionmentioning

confidence: 99%

The use of a novel bone allograft wash process to generate a biocompatible, mechanically stable and osteoinductive biological scaffold for use in bone tissue engineering

Smith

Richardson

Eagle

et al. 2014

J Tissue Eng Regen Med

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Fresh-frozen biological allograft remains the most effective substitute for the 'gold standard' autograft, sharing many of its osteogenic properties but, conversely, lacking viable osteogenic cells. Tissue engineering offers the opportunity to improve the osseointegration of this material through the addition of mesenchymal stem cells (MSCs). However, the presence of dead, immunogenic and potentially harmful bone marrow could hinder cell adhesion and differentiation, graft augmentation and incorporation, and wash procedures are therefore being utilized to remove the marrow, thereby improving the material's safety. To this end, we assessed the efficiency of a novel wash technique to produce a biocompatible, biological scaffold void of cellular material that was mechanically stable and had osteoinductive potential. The outcomes of our investigations demonstrated the efficient removal of marrow components (~99.6%), resulting in a biocompatible material with conserved biomechanical stability. Additionally, the scaffold was able to induce osteogenic differentiation of MSCs, with increases in osteogenic gene expression observed following extended culture. This study demonstrates the efficiency of the novel wash process and the potential of the resultant biological material to serve as a scaffold in bone allograft tissue engineering.

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“…The mechanical properties of cancellous bone, over a large range of strain rates, have been studied to better simulate and understand injuries sustained such as during a car crash (Chaary et al, 2007). Researchers have made great progress in characterizing the compressive behavior on cases of quasi-static loading (Guedes et al, 2006), and recently accounting for the influence of bone marrow (Halgrin et al, 2012;Charlebois et al, 2008). The few experimental studies entailing mechanical characterization at high strain rates have proved that the mechanical behavior is strain rate dependent (Linde et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

Links between mechanical behavior of cancellous bone and its microstructural properties under dynamic loading

Prot

Saletti

Pattofatto

et al. 2015

Journal of Biomechanics

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Previous studies show that in vivo assessment of fracture risk can be achieved by identifying the relationships between microarchitecture description from clinical imaging and mechanical properties. This study demonstrates that results obtained at low strain rates can be extrapolated to loadings with an order of magnitude similar to trauma such as car crashes. Cancellous bovine bone specimens were compressed under dynamic loadings (with and without confinement) and the mechanical response properties were identified, such as Young׳s modulus, ultimate stress, ultimate strain, and ultimate strain energy. Specimens were previously scanned with pQCT, and architectural and structural microstructure properties were identified, such as parameters of geometry, topology, connectivity and anisotropy. The usefulness of micro-architecture description studied was in agreement with statistics laws. Finally, the differences between dynamic confined and non-confined tests were assessed by the bone marrow influence and the cancellous bone response to different boundary conditions. Results indicate that architectural parameters, such as the bone volume fraction (BV/TV), are as strong determinants of mechanical response parameters as ultimate stress at high strain rates (p-value<0.001). This study reveals that cancellous bone response at high strain rates, under different boundary conditions, can be predicted from the architectural parameters, and that these relations with mechanical properties can be used to make fracture risk prediction at a determined magnitude.

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On the effect of marrow in the mechanical behavior and crush response of trabecular bone

Cited by 21 publications

References 15 publications

Fat and bone: the multiperspective analysis of a close relationship

Fat and bone: the multiperspective analysis of a close relationship

The use of a novel bone allograft wash process to generate a biocompatible, mechanically stable and osteoinductive biological scaffold for use in bone tissue engineering

Links between mechanical behavior of cancellous bone and its microstructural properties under dynamic loading

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