On the dynamic monitoring of the variations in blood viscosity by resonant optical signal

Abstract

This study concerns the development of sensors based on integrated photonics and resonator elements for monitoring the dynamic processes of sedimentation and drying of various bloods. The resonant structures of integrated photonics were produced and shaped on Si/SiO 2 and organic UV210 substrate, by deposition and microlithography processes allowing achieving patterns of sub-wavelength dimensions. The micro-resonators produced could be incorporated into a detection platform and fine measurements thermally controlled, were performed thanks to a specific signal processing by implemented codes. The analyses and monitoring over time of the different bloods were carried out with an identical defined protocol. The different bloods studied were sampled respectively from poultry, goats and humans with various characteristics in terms of red blood cell sizes, viscosities and densities. The analyzes relating to the sedimentation rates, the viscosity measurements by rheometer and the images of the red blood cells were carried out by different methods and apparatus for all the blood studied. These latest corroborated by our specific resonant measurements on integrated chip and sensors allow us to converge and conclude that the device and photonic chip sensor produced can discriminate the different bloods, with in the 1 st order, an equivalent and differential viscosity measurements. This work further proves that rheology by optical means (and not mechanically) is possible.

An innovative optical viscometer using a resonant surface signal

“…The speed rate of red blood cells is essential for medical diagnostics, while product quality monitoring is critical for petroleum products. 2,3 Optical cavities or micro-resonators (MRs) are have been widely used and integrated into photonic devices for diverse applications and research purposes. 4,5 They are commonly employed as sensors for chemical detection and biological applications.…”