On the distribution and fate of the carcinogenic hydrocarbon benzo[a]pyrene in soil

Shabad, L. M.

doi:10.1016/0015-6264(68)90291-5

Cited by 7 publications

(6 citation statements)

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“…Polycyclic aromatic hydrocarbons (PAH) are ubiguitous environmental pollutants and their role in carcinogenesis is well docu mented [1,2]. Almost all PAH undergo met abolic activation by mixed function oxidases (MFOs) and related enzymes [3.…”

Section: Introductionmentioning

confidence: 99%

In vitro Activation and Resultant Binding of Benzo[a]pyrene to DNA by Microsomes from Rats Fed Corn and Menhaden Oils

Dharwadkar¹,

Bellows²,

Ramanathan³

et al. 1986

Pharmacology

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Dietary unsaturated fat is required for maximum induction of the hepatic mixed function oxidases (MFO) responsible for activating carcinogens to forms that may bind covalently to DNA. The aim of this study was to assess the influence of dietary fat type and content on the activities of some enzymes involved in activation and detoxification of the carcinogen benzo[a]pyrene (B[a]P). Modification of these changes by pretreatment with phenobarbital (PB) was also evaluated. Male rats were fed diet devoid of fat or containing 20% corn oil (CO) or 20% menhaden fish oil (MO) for 4 days. PB induced soluble glutathione S-transferase, a detoxifying enzyme, only in rats fed dietary fats. Microsomes from rats fed both types of dietary fat had increased levels of cytochrome P-450 (P-450) and PB induced P-450 only in rats fed these fats. Although ethoxycoumarin O-dealkylase was significantly elevated in the MO group, the induction by PB was not dependent on dietary fat type or level. Dietary fat increased microsome-catalyzed in vitro binding of [³H]-B[a]P to calf thymus DNA, especially in response to PB. Menhaden oil depressed B[a]P hydroxylation and PB treatment depressed this activity to the greatest extent in rats fed this diet. When calculated as B[a]P metabolized per unit of P-450, PB seems to induce a P-450 in fat fed animals having lower affinity and capacity for B[a]P hydroxylation and activation than in rats fed the fat-free diet.

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Section: Introductionmentioning

confidence: 99%

In vitro Activation and Resultant Binding of Benzo[a]pyrene to DNA by Microsomes from Rats Fed Corn and Menhaden Oils

Dharwadkar¹,

Bellows²,

Ramanathan³

et al. 1986

Pharmacology

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“…This information will not, however, indicate the effect of soil incorporation on the toxic or mutagenic potential of hazardous waste. Poglazova et al (1967), Shabad et al (1971) and Khesina et al (1969) observed that the degradation of PAH by soil micro-organisms was significantly increased in a soil previously exposed to these compounds. Biodegradation will influence the mutagenic potential as it reduces the concentration of certain compounds and alters the reactivity of others.…”

Section: Discussionmentioning

confidence: 98%

Degradation of Soil Applied Organic Compounds From Three Petroleum Wastes

Brown

Donnelly

Thomas³

et al. 1985

Waste Manag Res

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The degradation rates of three industrial wastes were evaluated under simulated land treatment conditions. A wood-preserving bottom sediment, storm-water runoff impoundment sludge, and combined API-separator/slop-oil emulsion solid waste were applied to greenhouse boxes containing Norwood silt loam or Bastrop clay soils. Soil samples were collected before waste application and 0, 180, 360 and 540 days following application. Solvent extractable organic compounds were determined gravimetrically, and a GC/MS/DS system was used to identify major extractable organic constituents. The most rapid degradation rate over a 360 day period was observed in the Bastrop soil amended with the combined API separator/slop-oil emulsion solid waste. The half-lives of the total extractable hydrocarbons ranged from a low of 217 days for the combined API waste in the Bastrop soil to a high of 340 days for the storm-water runoff waste in the Norwood soil. Major residual organic constituents in the waste amended soil after 60 days incubation included pentachlorophenol, fluoranthene, pyrene, dihydro acenaphthylene, cyclopenta phenanthrene and trimethyl naphthalene. These results indicate that large quantities of oil hydrocarbons can be degraded by soil application, and significant differences in degradation rates will occur between different wastes and soils.

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“…Shabad et al [23] stated that the PAHs penetrated the soil mainly from air and spread intact across the layers into the water. They then passed into plants, fodder, and finally human food.…”

Section: Induction Of Mutation In Drosophila Melanogastermentioning

confidence: 99%

Induction of Mutation in Drosophila melanogaster fed a hexane extract of vegetables grown in soil contaminated with particulates from diesel engine exhaust

1999

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On the distribution and fate of the carcinogenic hydrocarbon benzo[a]pyrene in soil

Cited by 7 publications

References 0 publications

In vitro Activation and Resultant Binding of Benzo[a]pyrene to DNA by Microsomes from Rats Fed Corn and Menhaden Oils

In vitro Activation and Resultant Binding of Benzo[a]pyrene to DNA by Microsomes from Rats Fed Corn and Menhaden Oils

Degradation of Soil Applied Organic Compounds From Three Petroleum Wastes

Induction of Mutation in Drosophila melanogaster fed a hexane extract of vegetables grown in soil contaminated with particulates from diesel engine exhaust

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