“…The latter are usually mediated by the solvent and can be described by simple potentials, such as the Debye-Hückel potential, or by suitable mean field approximations [18,19,20,21]. Short range interactions, however, can produce important correlations between the binding to neighbouring sites, so that the continuous mean field approach is no longer valid [22,23]. Moreover, they are mediated by the molecular skeleton rather than by the solvent, so that they cannot in general be modelled by simple interaction potentials.…”