On the Development of Epidermal Methylcholanthrene Tumors in Mice Receiving Cortisone123

Actions of Cortisone on Cutaneous and Pulmonary Neoplasms Induced in Mice by Cutaneous Applications of Methylcholanthrene

“…However, our observations do support those of and of Boutwell and Rusch (1953). Nevertheless, it should be carefully noted, since it merits such special attention, that all the investigators who reported that cortisone suppresses experimentally-induced skin neoplasia, conducted their experiments for only relatively short periods, ranging from 21 days (Baker and Whitaker, 1949) to a maximum of 26 weeks (Piccagli et al, 1954), as opposed to the experiments reported on by Boutwell and Rusch, and by ourselves, which extended over very much longer periods (up to 33 and 38 weeks in our own experiments).…”

Hair Cycle and Chemically Induced Epidermal Carcinogenesis in Mice Receiving Liothyronine

“…Since in previous investigations includ ing our own [2,3,4, 5] the tum or incidence was low in response to DMBA application during the growing phase of the hair cycle (anagen) and augm ented in response to application during the resting phase (telogen), we had expected a decrease in the tum or incidence under the influence of Liothyronine. This, however, did not at all hold true.…”