On the detector arrangement for in-beam PET for hadron therapy monitoring

Crespo, Paulo; Shakirin, Georgy; Enghardt, W.

doi:10.1088/0031-9155/51/9/002

Cited by 116 publications

(103 citation statements)

References 18 publications

(23 reference statements)

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“…Original discussion and first investigations are reported in Ref. [57][58][59]. At present, after the experimentation at GSI, there is not yet a standard clinical implementation of PET monitoring in real time.…”

Section: Measurement Of β + Activitymentioning

confidence: 99%

Nuclear physics and particle therapy

Battistoni

Mattei

Muraro

2016

Advances in Physics: X

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The use of charged particles and nuclei in cancer therapy is one of the most successful cases of application of nuclear physics to medicine. The physical advantages in terms of precision and selectivity, combined with the biological properties of densely ionizing radiation, make charged particle approach a clinically preferred choice in a number of cases. Hadron therapy is in continuous development and nuclear physicists can give important contributions to this discipline. In this work, some of the relevant aspects in nuclear physics will be reviewed. ARTICLE HISTORY

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Section: Measurement Of β + Activitymentioning

confidence: 99%

Nuclear physics and particle therapy

Battistoni

Mattei

Muraro

2016

Advances in Physics: X

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“…Original discussion and first investigations are reported in ref. [14][15][16]. An example of recent research and development activity to design a device to be used in real time during clinical operation is reported in ref.…”

Section: In-beam Petmentioning

confidence: 99%

Nuclear physics and particle therapy

Battistoni

2016

EPJ Web of Conferences

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The use of charged particles and nuclei in cancer therapy is one of the most successful cases of application of nuclear physics to medicine. The physical advantages in terms of precision and selectivity, combined with the biological properties of densely ionizing radiation, make charged particle approach an elective choice in a number of cases. Hadron therapy is in continuous development and nuclear physicists can give important contributions to this discipline. In this work some of the relevant aspects in nuclear physics will be reviewed, summarizing the most important directions of research and development.

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“…Finally, we have studied the scatter fraction since the RPC-based PET has no energy information, necessary to discriminate scatter events. For a more elaborated method to assess the system response applied to hadrontherapy monitoring, the authors refer to Crespo et al (2006).…”

Section: Crystal-based Petmentioning

confidence: 99%

Evaluation of resistive-plate-chamber-based TOF-PET applied to in-beam particle therapy monitoring

Torres-Espallardó¹,

Diblen²,

Rohling³

et al. 2015

Phys. Med. Biol.

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Particle therapy is a highly conformal radiotherapy technique which reduces the dose deposited to the surrounding normal tissues. In order to fully exploit its advantages, treatment monitoring is necessary to minimize uncertainties related to the dose delivery. Up to now, the only clinically feasible technique for the monitoring of therapeutic irradiation with particle beams is Positron Emission Tomography (PET). In this work we have compared a Resistive Plate Chamber (RPC)-based PET scanner with a scintillation-crystal-based PET scanner for this application. In general, the main advantages of the RPC-PET system are its excellent timing resolution, low cost, and the possibility of building large area systems. We simulated a partial-ring scanner based on an RPC prototype under construction within the Fondazione per Adroterapia Oncologica (TERA). For comparison with the crystal-based PET scanner we have chosen the geometry of a commercially available PET scanner, the Philips Gemini TF. The coincidence time resolution used in the simulations takes into account the current achievable values as well as expected improvements of both technologies. Several scenarios (including patient data) have been simulated to evaluate the performance of different scanners. Initial results have shown that the low sensitivity of the RPC hampers its application to hadron- Note Institute of Physics and Engineering in Medicine6 These authors contributed equally to the work. beam monitoring, which has an intrinsically low positron yield compared to diagnostic PET. In addition, for in-beam PET there is a further data loss due to the partial ring configuration. In order to improve the performance of the RPC-based scanner, an improved version of the RPC detector (modifying the thickness of the gas and glass layers), providing a larger sensitivity, has been simulated and compared with an axially extended version of the crystal-based device. The improved version of the RPC shows better performance than the prototype, but the extended version of the crystal-based PET outperforms all other options.

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On the detector arrangement for in-beam PET for hadron therapy monitoring

Cited by 116 publications

References 18 publications

Nuclear physics and particle therapy

Nuclear physics and particle therapy

Nuclear physics and particle therapy

Evaluation of resistive-plate-chamber-based TOF-PET applied to in-beam particle therapy monitoring

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