On the design and fabrication by two-photon polymerization of a readily assembled micro-valve

Schizas, Charalampos; Melissinaki, Vasileia; Gaidukevičiūtė, Arūnė; Reinhardt, Carsten; Ohrt, Christoph; Dedoussis, V.; Chichkov, Boris N.; Fotakis, C.; Farsari, Maria; Karalekas, D.

doi:10.1007/s00170-009-2320-4

Cited by 102 publications

(72 citation statements)

References 20 publications

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“…Such values correspond to the venules of the human body [10]. In order to keep the blood flow distortion as lower as possible, special care was taken so that the internal surface of the valve is smooth.…”

Section: Micro-valve Designmentioning

confidence: 99%

“…As mentioned in [10], the dimensions of the proposed valve allow us to neglect the red cells and leukocytes of the blood without any significant error. In this way, the blood was considered incompressible and non-Newtonian with density ρ = 1040 kg/m 3 and viscosity μ, which is given by:…”

Section: Flow Performance Simulationsmentioning

confidence: 99%

“…There are few examples of the fabrication of micro check valves whose main role is to prohibit the reversal of blood flow in human veins. Schizas et al [10] have demonstrated the feasibility of fabricating a micro-valve with an internal moving piston rod. Additionally, it was reported that the stair-step effect was evident at some valve locations and that distortion was also evident inside the valve's rod seat reducing thus the designed interface gap.…”

Section: Introductionmentioning

confidence: 99%

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Design, Fabrication and Computational Characterization of a 3D Micro-Valve Built by Multi-Photon Polymerization

et al. 2014

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Abstract:We report on the design, modeling and fabrication by multi-photon polymerization of a complex medical fluidic device. The physical dimensions of the built micro-valve prototype are compared to those of its computer-designed model. Important fabrication issues such as achieving high dimensional resolution and ability to control distortion due to shrinkage are presented and discussed. The operational performance of both multi-photon and CAD-created models under steady blood flow conditions was evaluated and compared through computational fluid dynamics analysis.

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Section: Micro-valve Designmentioning

confidence: 99%

Section: Flow Performance Simulationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Design, Fabrication and Computational Characterization of a 3D Micro-Valve Built by Multi-Photon Polymerization

et al. 2014

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“…As the majority of the materials are bio-compatible [16,17], this approach was employed for the manufacturing of artificial scaffolds for cell proliferation studies [18,19], medical implants for tissue engineering [20,21] as well as regenerative medicine [22,23]. In all of the mentioned examples the materials were passive polymers sensitized only with a photoinitiator responsible for the efficient photostructuring [24].…”

Section: Introductionmentioning

confidence: 99%

Microfabrication of 3D metallic interconnects via direct laser writing and chemical metallization

Jonavičius¹,

Rekštytė²,

Malinauskas³

2014

Lith. J. Phys.

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We present a developed method based on direct laser writing (DLW) and chemical metallization (CM) for microfabrication of three-dimensional (3D) metallic structures. Such approach enables manufacturing of free-form electro-conductive interconnects which can be used in integrated electric circuits such as micro-opto-electro-mechanical systems (MOEMS). The proposed technique employing ultrafast high repetition rate lasers enables efficient fabrication of 3D microstructures on dielectric as well as conductive substrates. The produced polymer links out of organic-inorganic composite matrix after CM serve as interconnects of separate metallic contacts; their dimensions are: height 15 μm, width 5 μm, length 35-45 μm, and they could provide 300 nΩm resistivity measured in a macroscopic way. This proves the techniques potential for creating integrated 3D electric circuits at microscale.

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“…Multiphoton lithography can be highly advantageous over other techniques due to the localized nature of polymerization that can be employed for fabrication of highly complex 3D microstructures with spatial resolution far smaller than 100 nm using tightly focused beams beyond the diffraction limit 3,4 . This technique has found numerous applications in the fields of plasmonics 5 , memory devices 6 , photonic devices 7 , microelectromechanical systems (MEMS) 8 and chemical and biosensors 9 . Much of multi-photon laser writing has been carried out using titanium: sapphire femtosecond lasers operating at 780 nm wavelength.…”

mentioning

confidence: 99%

Microstructuring by Two-Photon Polymerization using a Sub-Nanosecond Laser

Kumar¹,

Ramakrishna²

2017

Current Science

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A multi-photon absorption-based laser writing system with sub-micrometer resolution has been developed using an inexpensive sub-nanosecond laser for two-and three-dimensional structuring in photosensitive resist materials. New combinations of commercially available photoresists such as SU-8 and AR-N 4340, and a photoinitiator (2, 4, diethyl-9H-thioxanten-9-one) with large two-photon absorption at 532 nm are shown to be effective in obtaining sub-micrometer line or dot resolution. Systematic studies of the resolution on the system and fabrication parameters such as laser power, writing speed, focusing arrangement, etc. have been carried out. The sub-nanosecond-based laser micro writer is an inexpensive alternative with similar capabilities as a femtosecond-based laser writer. This system is comparably effective and has much higher capabilities for 2D structuring in terms of the aspect ratio of the fabricated structures than conventional 2D laser micro writers.Keywords: Fabrication parameters, photoresists, subnanosecond laser, two-photon polymerization, writing system. DURING the past few decades, several nano/micro fabrication techniques such as electron beam lithography (EBL), focused ion beam (FIB) milling and photolithography have been developed for the fabrication of simple as well as complex nano/microstructures 1 . Conventional laser writing and FIB milling have been only partially successful for fabrication of 3D micro/nanostructures. The need for vacuum using EBL and FIB methods can be disadvantageous. Micro-stereo lithography is an alternative method for 3D micro fabrication 2 , but has its limitations in terms of spatial resolution and writing speed. Multiphoton lithography can be highly advantageous over other techniques due to the localized nature of polymerization that can be employed for fabrication of highly complex 3D microstructures with spatial resolution far smaller than 100 nm using tightly focused beams beyond the diffraction limit 3,4 . This technique has found numerous applications in the fields of plasmonics 5 , memory devices 6 , photonic devices 7 , microelectromechanical systems (MEMS) 8 and chemical and biosensors 9 . Much of multi-photon laser writing has been carried out using titanium: sapphire femtosecond lasers operating at 780 nm wavelength. Although the ultrashort pulses are efficient for multi-photon polymerization, they are associated with high equipment cost. This can be offset by picosecond or sub-nanosecond lasers and using photointiators with large two-photon absorption cross-sections to obtain sub-wavelength resolution. He et al. 10 have reported a series of multi-photon absorbing materials that can be used for multi-photon polymerization using picosecond and sub-nanosecond lasers. Chung et al.11 have reported 3D micro-structuring using a low-cost Q-switched Nd : YAG microlaser. Other groups have utilized hybrid organic-inorganic resist such as SZ2080 (ORMOSIL) for the fabrication of high-resolution structures with picosecond lasers. Also, 2,4-diethyl-9H-thioxanten-9-one...

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On the design and fabrication by two-photon polymerization of a readily assembled micro-valve

Cited by 102 publications

References 20 publications

Design, Fabrication and Computational Characterization of a 3D Micro-Valve Built by Multi-Photon Polymerization

Design, Fabrication and Computational Characterization of a 3D Micro-Valve Built by Multi-Photon Polymerization

Microfabrication of 3D metallic interconnects via direct laser writing and chemical metallization

Microstructuring by Two-Photon Polymerization using a Sub-Nanosecond Laser

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