On the Deiters cell contribution to the micromechanics of the organ of Corti

Laffon, Éric; Angelini, Emmanuelle

doi:10.1016/s0378-5955(96)00089-5

Cited by 17 publications

(10 citation statements)

References 11 publications

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“…To estimate the mass of the DC, we used the morphological data from Zhao (2005). We approximated the shape of the cell by a prolate spheroid (Laffon and Angelini 1996) and assumed that the cell's density is close to that of the water (10 3 kg/m 3 ). The stiffness of the DC was estimated as 25 N/m (Tolomeo and Holley 1997).…”

Section: Effect Of the Constraint Stiffnessmentioning

confidence: 99%

High-Frequency Force Generation in the Constrained Cochlear Outer Hair Cell: A Model Study

Liao

Popel

Brownell

et al. 2005

JARO

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Cochlear outer hair cell (OHC) electromotility is believed to be responsible for the sensitivity and frequency selectivity of the mammalian hearing process. Its contribution to hearing is better understood by examining the force generated by the OHC as a feedback to vibration of the basilar membrane (BM). In this study, we examine the effects of the constraints imposed on the OHC and of the surrounding fluids on the cell's high-frequency active force generated under in vitro and in vivo conditions. The OHC is modeled as a viscoelastic and piezoelectric cylindrical shell coupled with viscous intracellular and extracellular fluids, and the constraint is represented by a spring with adjustable stiffness. The solution is obtained in the form of a Fourier series. The model results are consistent with previously reported experiments under both low-and high-frequency conditions. We find that constrained OHCs achieve a much higher corner frequency than free OHCs, depending on the stiffness of the constraint. We analyze cases in which the stiffness of the constraint is similar to that of the BM, reticular lamina, and tectorial membrane, and find that the force per unit transmembrane potential generated by the OHC can be constant up to several tens of kHz. This model, describing the OHC as a local amplifier, can be incorporated into a global cochlear model that considers cochlear hydrodynamics and frequency modulation of the receptor potential, as well as the graded BM stiffness and OHC length.

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Section: Effect Of the Constraint Stiffnessmentioning

confidence: 99%

High-Frequency Force Generation in the Constrained Cochlear Outer Hair Cell: A Model Study

Liao

Popel

Brownell

et al. 2005

JARO

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“…Previous experiments showed the involvement of Deiters cells in the micromechanics of the organ of Corti [4]. Stiffness change of the phalangeal process of these cells can be in the background of this observation, which may help to the active micromechanics of the organ of Corti [17]. Different neurotransmitters such as ATP can modify the stiffness of the Deiters cell phalangeal process.…”

Section: Introductionmentioning

confidence: 52%

“…Among the supporting cells, Deiters cells are in close contact at the apical and at the basal pole to the OHCs. In situ, the bodies of the OHCs are positioned between the bodies and ends of the phalangeal processes of the Deiters cells [17]. The length of the OHCs and, therefore, the length of the phalanx of the Deiters cells process depend on their position in the organ of Corti [20].…”

Section: Introductionmentioning

confidence: 99%

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Differential expression of potassium currents in Deiters cells of the guinea pig cochlea

Szűcs

Somodi

Batta

et al. 2006

Pflugers Arch - Eur J Physiol

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Among the supporting cells, Deiters cells are in intimate contact with outer hair cells (OHCs) in the inner ear. The aim of this study was to characterize the outward rectifying K+ current of Deiters cells in conjunction with cellular morphological characteristics. In the majority of cells, the K+ current had a biphasic inactivation kinetics (tau1 and tau2 were 2,735+/-90 (n=77) and 160+/-14 ms (n=72), respectively). The rapidly inactivating current component was more sensitive to Charybdotoxin (ChTx, 10 nM) block whereas the slowly inactivating current could be blocked more efficiently by tetraethylammonium (1 mM). All these point toward the existence of two distinct potassium channel types in these cells. Deiters cells attached to shorter OHCs had more voluminous, whereas those attached to longer OHCs had lanky cell bodies. The inactivation kinetics was slower in cells having corpulent cell bodies due to the increased proportion of the slowly inactivating current component (0.736+/-0.033, n=27) as compared to the one determined for lanky cells (0.522+/-0.023, n=36). The average peak K+ current was higher in Deiters cells connected to OHCs (5,417+/-541 pA, n=40) than in isolated ones (3,527+/-410, n=37). Deiters cells having different cell shapes and showing different K+ channel expression may contribute to the active mechanism of the cochlea to various degrees.

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“…They consist of Deiters' rods (l rod = 38.5 Ìm) and their Php (l Php = 62.9 Ìm). Their average Young's modulus was recently determined again (E DC = 45 MPa) [7].…”

Section: Morphology and Methodsmentioning

confidence: 99%

Active Nonlinear Mechanics of the Organof C orti Including the Stereocilia-Tectorial Membrane Complex

Böhnke¹,

Mikusch-Buchberg²,

Arnold³

1999

ORL

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There is a large amount of knowledge about the different components of the organ of Corti (OC), but little is known about how these components act together in vivo. To clarify the complex mechanical behavior of the OC, anatomic results are carefully analyzed and used to develop a finite element model of a short section of OC, which includes 8 outer hair cells (OHC) and their supporting structures. The modal analysis shows the frequency-dependent phase reversal of the radial stereocilia displacement. The transient computation confirms the amplification of OC displacements when the ability of the OHC to contract and elongate is considered. The inclusion of a nonlinear function describing the mechanoelectrical transduction in OHC amplifies and distorts the displacement of the OC when it is stimulated by a sinusoidal input pressure function. These results are in agreement with other psychoacoustic, electrophysiologic and otoacoustic measurements.

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On the Deiters cell contribution to the micromechanics of the organ of Corti

Cited by 17 publications

References 11 publications

High-Frequency Force Generation in the Constrained Cochlear Outer Hair Cell: A Model Study

High-Frequency Force Generation in the Constrained Cochlear Outer Hair Cell: A Model Study

Differential expression of potassium currents in Deiters cells of the guinea pig cochlea

Active Nonlinear Mechanics of the Organof C orti Including the Stereocilia-Tectorial Membrane Complex

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