On the consensus nomenclature rules for radiopharmaceutical chemistry – Reconsideration of radiochemical conversion

Direct Cu-mediated aromatic 18F-labeling of highly reactive tetrazines for pretargeted bioorthogonal PET imaging

“…The radiochemical conversion (RCC) was approximately 14% at the first attempt (Figure 2A). 53 However, only the stannane precursors of more reactive Tzs could be synthesized. Boronic ester precursors decomposed (SI, Section S2).…”

Fully Automated GMP-Compliant Synthesis of [18F]FE-PE2I

“…The reaction was optimized using 1 mg precursor per synthesis. The highest radiochemical conversion (RCC) [ 13 ] of [ 18 F]FE-PE2I was reported to be reached using DMSO or DMF as a solvent at 140 °C for 5 min [ 10 ]. Using this as a starting point, the stability of the precursor and the reference compound (FE-PE2I) was analyzed using two different methods for elution of the trapped [ 18 F]fluoride from the anion exchange cartridge.…”

Preliminary Investigation of a Novel

“…Reaction parameters were varied in the process as follows: reaction temperature: 110-1908C, reactants residence time: 9.4-93.8 s, and mass of precursor: 178.5-2380 mg. The crude reaction mixtures were analyzed by both radio-HPLC and radio-TLC, reporting similar overall trends but radiochemical conversion (RCC) [11,12] calculated from TLC was higher than from HPLC.…”

“…This condition, added to the reported variability in recovering the radiofluorinating mixture, [18] made it difficult to evaluate the radiochemical yield (RCY) of the process for each production run. [11,12] In this case, we evaluated this parameter by assessing the total radioactive content of the bolus reaction; this value was obtained performing a new sample radiofluorination reaction at EOS and measuring it for radioactivity content. By this method, we obtained a RCY of 29 AE 12 %, which is lower than the RCC, but still allowed the scan of up to three subjects per production run during imaging sessions.…”