When studying the behavior of autonomous ordinary differential equations under time-dependent perturbations vanishing for → ±∞, their equilibria generically persist locally as homoclinic solutions. Using an abstract and flexible continuation theorem, we find even global branches of such homoclinic solutions for parametrized nonautonomous ordinary differential equations. Our approach is based on degreetheoretical arguments. In particular, Landesman-Lazer conditions are proposed to obtain the existence of homoclinic solutions by means of a nonzero degree. K E Y W O R D S exponential dichotomy, homoclinic solution, Landesman-Lazer condition M S C ( 2 0 1 0 ) Primary: 37J45, 47H11, Secondary: 34C37, 34A12 1174