We study Subgraph Isomorphism on graph classes defined by a fixed forbidden graph. Although there are several ways for forbidding a graph, we observe that it is reasonable to focus on the minor relation since other well-known relations lead to either trivial or equivalent problems. When the forbidden minor is connected, we present a near dichotomy of the complexity of Subgraph Isomorphism with respect to the forbidden minor, where the only unsettled case is P5, the path of five vertices. We then also consider the general case of possibly disconnected forbidden minors. We show fixed-parameter tractable cases and randomized XP-time solvable cases parameterized by the size of the forbidden minor H. We also show that by slightly generalizing the tractable cases, the problem becomes NP-complete. All unsettle cases are equivalent to P5 or the disjoint union of two P5's. As a byproduct, we show that Subgraph Isomorphism is fixed-parameter tractable parameterized by vertex integrity. Using similar techniques, we also observe that Subgraph Isomorphism is fixed-parameter tractable parameterized by neighborhood diversity.