In this paper, a quick and efficient means of determining stress intensity factors, K~ and Kn, for cracks in generally orthotropic elastic bodies is presented using the numerical boundary integral equation (BIE) method. It is based on the use of quarter-point singular crack-tip elements in the quadratic isoparametric element formulation, similar to those commonly employed in the BIE fracture mechanics studies in isotropic elasticity. Analytical expressions which enable K~ and K u to be obtained directly from the BIE computed crack-tip nodal traction, or from the computed nodal displacements, of these elements are derived. Numerical results for a number of test problems are compared with those established in the literature. They are accurate even when only a very modest number of boundary elements are used.