The global pharmaceutical market is evolving rapidly. The pharmaceutical industry is one of the industries that can significantly contribute to the economic development and creation of added value. This industry, in many countries, has evolved technologically and most pharmaceutical companies are active in the Research-Development field. The research follows the spatial design of the dynamics of drug production, an economic activity with a spectacular dynamic in recent years. The study was carried out starting from a database that includes the number of employees, turnover, profit and number of companies in this field, for the period 2000-2018. In order to obtain the spatial dynamics, a series of cartographic models were developed for the four indicators, using the opensource QGis platform. The obtained results highlighted a series of regional specificities determined by the tradition of drug production and particular developments generated by the manifestation of the economic crisis in Romania.