We prove that if an F-lattice E is locally bounded (i.e., an open ball in E centered at 0 is topologically bounded) then every orthomorphism in E is central: Or th(E) = Z (E). This solves partially a problem raised recently by Chil and Meyer.For the Nakano (non-Banach) F-lattice E = ℓ ( p n ) , 0 < p n < 1, the above implication becomes an equivalence.We also study the problem of central orthomorphism in the class of (non-Banach) Musielak-Orlicz sequence spaces ℓ Φ . We give a sufficient condition on Φ for a non-central orthomorphism on ℓ Φ to exist.