2007
DOI: 10.1016/j.biomaterials.2006.10.023
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On the biology of saphenous vein grafts fitted with external synthetic sheaths and stents

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Cited by 81 publications
(94 citation statements)
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“…Mechanical external stents for SVGs have shown considerable promise in pre-clinical testing with reduction of proliferative intimal hyperplasia by reducing wall tension, improving lumen uniformity and creating a protective "neo-adventitia" layer rich with micro vasculature (11)(12)(13). However, limited clinical data has been published to date with such devices.…”
Section: Introductionmentioning
confidence: 99%
“…Mechanical external stents for SVGs have shown considerable promise in pre-clinical testing with reduction of proliferative intimal hyperplasia by reducing wall tension, improving lumen uniformity and creating a protective "neo-adventitia" layer rich with micro vasculature (11)(12)(13). However, limited clinical data has been published to date with such devices.…”
Section: Introductionmentioning
confidence: 99%
“…Mechanical external stents for SVGs have shown significant reductions of proliferative intimal hyperplasia, foam cells deposition, and other vascular disease markers in pre-clinical testing (10)(11)(12)(13). This protective effect of external stents is attributed to the reduction in SVG wall tension, the improvement of lumen uniformity and the formation of a "neo-adventitia" layer rich with micro vasculature (10)(11)(12)(13)(14).…”
Section: Introductionmentioning
confidence: 99%
“…This protective effect of external stents is attributed to the reduction in SVG wall tension, the improvement of lumen uniformity and the formation of a "neo-adventitia" layer rich with micro vasculature (10)(11)(12)(13)(14). The VEST (Vascular Graft Solutions Ltd, Tel Aviv, Israel) is a kink resistant cobalt-chromium braided mesh, applied externally to the vein graft during surgery.…”
Section: Introductionmentioning
confidence: 99%
“…After harvesting, the perivenous vasa vasorum fails to function effectively and cells migrate towards the inner layers, where oxygen is diffusing from the arterial circulation. Pre-clinical research has shown that external support affects venous wall remodeling by facilitating adventitial neovascularization which is critical to prevent migration of cells from the media and adventitia towards the inner layers [22]. In addition, external support may have a role in redirecting vascular smooth muscle cell migration through a reversed chemotactic gradient.…”
Section: Resultsmentioning
confidence: 99%