On the Biological Importance, Preparation, and Uses of Imidazo[1,2-b]pyridazine-Based Compounds

Abstract

While studying several pyridazine compounds, the author discovered imidazo[1,2-b]pyridazine (IMP), which is a very versatile compound class. It has been an inhibitor for many enzymes and also it is used as a brominating reagent in organic syntheses. Owing to its high biological activity, researchers have always considered including this molecule in their final structures. This humble attempt just aims to introduce this very powerful molecule to the readers, primarily of chemical origin, and should not be considered as a full treatise of, especially, the medicinal chemistry of the molecule. This work discusses the inhibitory effects, organic chemistry, applications in material chemistry, and theoretical studies of IMP and related molecules. The readers are hereby encouraged to work with medicinal chemists with the newly prepared molecules including this and similar molecules, in the struggle with many diseases like cancer, Alzheimer’s, and others.

Exploring the untapped pharmacological potential of imidazopyridazines

“…As mentioned imidazo[1,2- b ]pyridazines are widely explored compared to imidazo[4,5- c ]pyridazines and imidazo[4,5- d ]pyridazines. The pharmacological potential of these imidazo[1,2- b ]pyridazines has been investigated by different research groups; 14,15 however, the developments in all the imidazopyridazine isomers have not been reviewed. In the present review, we focus on the development of imidazopyridazine derivatives as potential pharmacological agents, which will be helpful to readers interested in exploring this relatively less charted area by designing of the new imidazopyridazine-based compounds.…”