On the behavior of quercetin + organic solvent solutions and their role for C60 fullerene solubilization

Tamayo-Ramos, Juan Antonio; Martel-Martín, Sonia; Barros, Rocío; Bol, Alfredo; Aparício, Santiago

doi:10.1016/j.molliq.2021.117714

Cited by 4 publications

(2 citation statements)

References 55 publications

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“…One effective way to prevent this is the combination of C60-quercetin solutions (Scheme 9). As a result, the solubilization of C60 with quercetin leads to more biodegradable materials [139]. In recent years, scientists have achieved the synthesis of novel C60 fullerene-flavone derivatives, starting from quercetin, via cyclopropanation (Bingel reaction) of C60.…”

Section: Additive Treatment Of Diseasementioning

confidence: 99%

Quercetin: A Potential Polydynamic Drug

Georgiou,

Kakava,

Routsi

et al. 2023

Molecules

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The study of natural products as potential drug leads has gained tremendous research interest. Quercetin is one of those natural products. It belongs to the family of flavonoids and, more specifically, flavonols. This review summarizes the beneficial pharmaceutical effects of quercetin, such as its anti-cancer, anti-inflammatory, and antimicrobial properties, which are some of the quercetin effects described in this review. Nevertheless, quercetin shows poor bioavailability and low solubility. For this reason, its encapsulation in macromolecules increases its bioavailability and therefore pharmaceutical efficiency. In this review, a brief description of the different forms of encapsulation of quercetin are described, and new ones are proposed. The beneficial effects of applying new pharmaceutical forms of nanotechnology are outlined.

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Section: Additive Treatment Of Diseasementioning

confidence: 99%

Quercetin: A Potential Polydynamic Drug

Georgiou,

Kakava,

Routsi

et al. 2023

Molecules

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“…The previous study investigated the preferential solvation of flavonoid molecules by DMSO over water, resulting in an enhanced solubility of flavonoids (28) . Two primary factors influence flavonoid solubilization and solute-solvent interactions, namely: (i) the impact of hydrogen bonding and (ii) the phenomenon of preferential solvation in mixed fluids, specifically referring to nanoscopic local heterogeneity (29) .…”

Section: Formulation Of Kenikir Leaf Extractmentioning

confidence: 99%

Cosmos caudatus Kunth. Leaf Extract Herbal Nanosuspension Formulations, Characterization, and Cytotoxicity Approach Against MCF-7 Breast Cancer Cells

Nafisa,

Noor,

Azkannufuus

et al. 2023

Indonesian. J. Pharm. Sci.

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Kenikir leaves (Cosmos caudatus Kunth.) contain quercetin, which has anticancer properties. To provide more effective complementary therapy for breast cancer, nanotechnology was applied to develop preparations containing kenikir leaf extract. This research aimed to formulate a nanosuspension containing kenikir leaf extract with cytotoxic activity against MCF-7 breast cancer cells. Nanosuspension of kenikir leaf extract was prepared using the ionic gelation method with 3%, 4%, and 5% PVP K-30 stabilizer. The nanosuspension formula with the highest entrapment efficiency was further characterised, including particle size, polydispersity index (PDI), zeta potential, pH, and particle morphology. Cytotoxic activity was tested against MCF-7 cells by the MTT assay. The results showed that the formula with 5% PVP has the highest entrapment efficiency value of 85.04±0.08%, a particle size of 221.9 nm, a PDI of 0.211, a zeta potential of -21.7 mV, a pH of 4.08±0.0, and a spherical morphology. The kenikir leaf extract at a concentration of 1 mg/mL inhibited the proliferation of MCF-7 cells by 23.4% (p<0.05), whereas the nanosuspension at 10 μg/mL inhibited proliferation by 23.7%. It can be concluded that kenikir leaf extract can be formulated into a nanosuspension that meets the physical criteria and has cytotoxic activity against MCF-7 cells.

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