On the Behavior of Hemophilus Influenzae in Certain Diseases of Children

Huntington, Robert W.

doi:10.1172/jci100696

Cited by 8 publications

(3 citation statements)

References 9 publications

(11 reference statements)

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“…Der Einteilung bakterieller Oberflachenkolonien in M-(mucoid), S-(smooth), R-(rough) und in verschiedene Intermediarformen folgend, gehoren die Kolonien der iridisierenden Variante zur M-und die der nicht iridisierenden Variante zur R-Form. Diese Differenzierung befindet sich in Ubereinstimmung mit der von Huntington (1935) und Chandler etal. (1939 vorgenommenen und von Turk und May (1967) vorgeschlagenen Unterscheidung von H. wj/7«enzae-Oberflachenkolonien der M-(bekapselt und iridisierend), S-(glatte, nicht bekapselte und nicht iridisierende Kolonien) und R-Form (rauhe, nicht bekapselte und nicht iridisierende Kolonien).…”

Section: Vioo83unclassified

Beitrag zur differenzierung von haemophilus‐ stämmen aus hühnern IV. Mitteilung: Untersuchungen über die dissoziation von haemophilus paragallinarum

Hinz

1976

Avian Pathology

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Bacteria of 2 phenotypic forms of one strain of Haemophilus paragallinarum were morphologically, culturally, biochemically and serologically investigated. On transparent solid media bacteria of the M variant (mucoid) were capsulated and showed iridescence in oblique transmitted light throughout the first 8-14 hours of incubation. Iridescence disappeared completely after 36 hours incubation. Bacteria of this variant formed stable homogeneous suspensions in 0.15 M NaCl and an homogeneous cloudiness after growth in liquid media. A type specific soluble substance was found in fluid culture filtrates and in bacterial washings using the indirect haemagglutination test. Bacteria of the R variant (rough) derived by dissociation of iridescent colonies were not capsulated and showed no iridescence throughout 8-14 hours incubation (minus variant). This bacteria showed spontaneous agglutination in 0.15 M NaCl and a granular growth in liquid media. There were no biochemical differences between M and R variant. A type specific substance was not found in the R bacteria using the indirect haemagglutination test. In the plate agglutination test no serological reaction between anti-K-sera and M antigen were observed. R to M variation occurred in SPF chickens following intranasal inoculation of organisms of R cultures grown for 6 or 20 passages on solid medium.

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Section: Vioo83unclassified

Beitrag zur differenzierung von haemophilus‐ stämmen aus hühnern IV. Mitteilung: Untersuchungen über die dissoziation von haemophilus paragallinarum

Hinz

1976

Avian Pathology

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“…The S strains were found to be more pathogenic for laboratory animals than the R strains. Huntington (1935), referring to Dawson's classification of the pneumococci, suggested that the same terminology be adopted to designate the dissociative pattern of H. influenzae. Accord-ingly, he applied the term "mucoid" to the strains which produced mucoid, fluorescent colonies, capsulated organisms and soluble specific substance (i.e., Pittman's S).…”

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confidence: 99%

The Pattern of Dissociation inHemophilus influenzae

1939

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In recent communications, Hadley (1937), Dawson (1934) and others have pointed out that most, if not all microorganisms exhibit a similar dissociative pattern. Dawson (1934, 1938), in studies on the pneumococci and the hemolytic streptococci in particular, has shown that the pattern of variation in these two organisms is strikingly similar. In view of this, both Dawson and Hadley have proposed that a uniform nomenclature for all microorganisms be adopted to designate the three chief phases of dissociation-i.e., mucoid (M), smooth (S) and rough (R). In 1931, Pittman described a smooth and a rough form for Hemophilus influenzae. Smooth strains were characterized by

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“…The latter have also been desig nated R colonies. However, H untington [13] suggested in 1934 a change in the terminology used for H. influenzae strains. He followed the terminology proposed for pneumococci by D awson [7] and designated the iridescent strains as M, the non-iridescent strains as S, reserving R for distinct rough variants.…”

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confidence: 99%

Serological Studies of <i>Haemophilus influenzae</i>

Branefors-Helander¹

1972

Int Arch Allergy Immunol

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Six capsulated Haemophilus influenzae strains, types a to f (Ma–Mf), and two non-iridescent, non-capsulated variants of the Ma and Md strains (Sa and Sd) were studied by means of double immunodiffusion and immuno-electrophoretic methods. A capsular antigen, designated precipitinogen 1, and a second antigen, designated precipitinogen 2, were demonstrated in extracellular (Ex) antigen preparations of the Ma–Mf strains. In addition to the serotvpe capsular antigen, traces of capsular antigen of at least one other serotype could be demonstrated in all Ex antigen preparations except in MaEx. In strain Sa, small amounts of capsular antigen a were found, whereas no capsular antigen d was revealed in the strain Sd. The precipitinogens 2 of the Ma and Md strains were also demonstrated in the S variants, indicating that this antigen may not be of capsular origin. Cross-reactions of precipitinogen 2 were seen between strains of three different serotypes (a, e and f).

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On the Behavior of Hemophilus Influenzae in Certain Diseases of Children

Cited by 8 publications

References 9 publications

Beitrag zur differenzierung von haemophilus‐ stämmen aus hühnern IV. Mitteilung: Untersuchungen über die dissoziation von haemophilus paragallinarum

Beitrag zur differenzierung von haemophilus‐ stämmen aus hühnern IV. Mitteilung: Untersuchungen über die dissoziation von haemophilus paragallinarum

The Pattern of Dissociation inHemophilus influenzae

Serological Studies of <i>Haemophilus influenzae</i>

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