A multiple stream process consists of several identical process streams. We present the process yield index SpkM for multiple stream processes with individual observations. An approximate distribution of the estimator of SpkM is derived. A simulation study is conducted to evaluate the performance of the confidence interval using the proposed method and the existing method. The simulation results show that the proposed method outperforms the existing method regarding interval length. We extend this process yield index for the case of subsamples. An approximate distribution for the estimator of Spk,sM is also derived. Two real examples are used to demonstrate the performance of the proposed approach. Copyright © 2015 John Wiley & Sons, Ltd.