On the assembly of zwitterionic block copolymers with phospholipids

Spanjers, Järvi; Brodszkij, Edit; Gal, Noga; Pedersen, Jan Skov; Städler, Brigitte

doi:10.1016/j.eurpolymj.2022.111612

Cited by 1 publication

(1 citation statement)

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“…Fluorescence spectroscopy (FS) is another useful technique for exploring lipid and lipid/copolymer nanoparticle coassembly properties. In fact, the membrane mechanics of such systems could be investigated by utilizing the Laurdan probe. − Laurdan is a hydrophobic probe which can be embedded into the hydrophobic parts of the lipid/polymer nanoparticles and elicit information about their internal microfluidity …”

Section: Introductionmentioning

confidence: 99%

Deciphering the Lipid-Random Copolymer Interactions and Encoding Their Properties to Design a Hybrid System

Triantafyllopoulou,

Forys,

Perinelli

et al. 2024

Langmuir

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Lipid/copolymer colloidal systems are deemed hybrid materials with unique properties and functionalities. Their hybrid nature leads to complex interfacial phenomena, which have not been fully encoded yet, navigating their properties. Moving toward in-depth knowledge of such systems, a comprehensive investigation of them is imperative. In the present study, hybrid lipid/copolymer structures were fabricated and examined by a gamut of techniques, including dynamic light scattering, fluorescence spectroscopy, cryogenic transmission electron microscopy, microcalorimetry, and high-resolution ultrasound spectroscopy. The biomaterials that were mixed for this purpose at different ratios were 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine and four different linear, statistical (random) amphiphilic copolymers, consisting of oligo(ethylene glycol) methyl ether methacrylate as the hydrophilic comonomer and lauryl methacrylate as the hydrophobic one. The colloidal dispersions were studied for lipid/copolymer interactions regarding their physicochemical, morphological, and biophysical behavior. Their membrane properties and interactions with serum proteins were also studied. The aforementioned techniques confirmed the hybrid nature of the systems and the location of the copolymer in the structure. More importantly, the random architecture of the copolymers, the hydrophobic-to-hydrophilic balance of the nanoplatforms, and the lipid-to-polymer ratio are highlighted as the main design-influencing factors. Elucidating the lipid/copolymer interactions would contribute to the translation of hybrid nanoparticle performance and, thus, their rational design for multiple applications, including drug delivery.

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