On the applicability of bovine morsellized cortico-cancellous bone as a substitute for human morsellized cortico-cancellous bone for in vitro mechanical testing

Morsellised sawbones is an acceptable experimental substitute for the in vitro elastic and viscoelastic mechanical characterisation of morsellised cancellous bone undergoing impaction grafting

“…Unfortunately, direct comparison of findings across different experimental studies is problematic due to the lack of standardisation in (i) the test configuration (e.g. Butler et al [40] , Lunde et al ( [41]), Putzer et al [33], Aquarius et al [42], Bolland et al [43]; (ii) the magnitude and frequency of loading (Bavadekar et al [19], Fosse et al [23], Grimm [18], Voor et al [22]; (iv) the origin and treatment of the bone chips (Cornu et al [20], Datta et al [13], Lunde et al ( [44]). One approach that potentially alleviates the difficulties of comparison across studies is to use experimental protocols which enable the bone graft material to be characterised using consolidation models from soil mechanics, such as the Drucker-Prager and Mohr-Coulomb yield criteria.…”