On the antioxidant activity of melatonin

Antunes, Fernando; Barclay, L. R. C.; Ingold, K. U.; King, Mary C.; Norris, James Q.; Scaiano, J. C.; Xi, Fengde

doi:10.1016/s0891-5849(98)00168-3

Cited by 119 publications

(73 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the basis of their results they concluded that melatonin's ability to scavenger the peroxyl radical was moderate compared to that of vitamin E. The results of Longoni et al [50] also led them to the conclusion that melatonin is certainly less effective than vitamin E in the systems they used to neutralize the lipoperoxyl radical. In possibly the most thorough study published to date, Antunes et al [6] claimed that melatonin's ability as a lipoperoxyl radical scavenger is weak.…”

Section: Peroxyl Radicalsmentioning

confidence: 99%

Actions of Melatonin in the Reduction of Oxidative Stress

et al. 2000

View full text Add to dashboard Cite

Melatonin was discovered to be a direct free radical scavenger less than 10 years ago. Besides its ability to directly neutralize a number of free radicals and reactive oxygen and nitrogen species, it stimulates several antioxidative enzymes which increase its efficiency as an antioxidant. In terms of direct free radical scavenging, melatonin interacts with the highly toxic hydroxyl radical with a rate constant equivalent to that of other highly efficient hydroxyl radical scavengers. Additionally, melatonin reportedly neutralizes hydrogen peroxide, singlet oxygen, peroxynitrite anion, nitric oxide and hypochlorous acid. The following antioxidative enzymes are also stimulated by melatonin: superoxide dismutase, glutathione peroxidase and glutathione reductase. Melatonin has been widely used as a protective agent against a wide variety of processes and agents that damage tissues via free radical mechanisms.

show abstract

Section: Peroxyl Radicalsmentioning

confidence: 99%

Actions of Melatonin in the Reduction of Oxidative Stress

et al. 2000

View full text Add to dashboard Cite

show abstract

“…Early studies by Pieri et al (1994Pieri et al ( , 1995 claimed that melatonin was a more e cient LOOd scavenger than is vitamin E, considered the premier chain-breaking antioxidant. This claim, however, has not been veri® ed in subsequent studies (Livrea et al 1997 ;Antunes et al 1999). Thus, it appears that melatonin' s ability to reduce lipid peroxidation in-vivo is probably not related to its function as a chain-breaking antioxidant but could be associated with melatonin' s ability to scavenge the initiating radicals and to other actions within the molecular lipid bilayer (Garcia et al 1997Tesoriere et al 1999).…”

Section: Melatonin : Direct Scavenging Actionsmentioning

confidence: 99%

Melatonin: reducing the toxicity and increasing the efficacy of drugs

Reíter¹,

Tan²,

Sainz³

et al. 2002

Journal of Pharmacy and Pharmacology

378

300

View full text Add to dashboard Cite

Melatonin (N-acetyl-5-methoxytryptamine) is a molecule with a very wide phylogenetic distribution from plants to man. In vertebrates, melatonin was initially thought to be exclusively of pineal origin ; recent studies have shown, however, that melatonin synthesis may occur in a variety of cells and organs. The concentration of melatonin within body uids and subcellular compartments varies widely, with blood levels of the indole being lower than those at many other sites. Thus, when de ning what constitutes a physiological level of melatonin, it must be de ned relative to a speci c compartment. Melatonin has been shown to have a variety of functions, and research in the last decade has proven the indole to be both a direct free radical scavenger and indirect antioxidant. Because of these actions, and possibly others that remain to be de ned, melatonin has been shown to reduce the toxicity and increase the ef cacy of a large number of drugs whose side effects are well documented. Herein, we summarize the bene cial effects of melatonin when combined with the following drugs: doxorubicin, cisplatin, epirubicin, cytarabine, bleomycin, gentamicin, ciclosporin, indometacin, acetylsalicylic acid, ranitidine, omeprazole, isoniazid, iron and erythropoietin, phenobarbital, carbamazepine, haloperidol, caposide-50, morphine, cyclophosphamide and L-cysteine. While the majority of these studies were conducted using animals, a number of the investigations also used man. Considering the low toxicity of melatonin and its ability to reduce the side effects and increase the ef cacy of these drugs, its use as a combination therapy with these agents seems important and worthy of pursuit.

show abstract

“…Apart from its direct ROS-scavenging activity, it also increases the expression of antioxidant defense system enzymes such as superoxide dismutase (SOD), catalase, and the glutathione (GSH) system [16,17] . The anti-inflammatory properties of melatonin have been reported in several studies [18,19] .…”

mentioning

confidence: 99%

Effect of Melatonin and Resveratrol against Memory Impairment and Hippocampal Damage in a Rat Model of Vascular Dementia

Shen¹,

Tian²,

Sang³

et al. 2016

Neuroimmunomodulation

View full text Add to dashboard Cite

Objectives: This study was intended to investigate whether treatment with resveratrol and melatonin alone or in combination can exert neurorestorative effects in a rat model of vascular dementia. Methods: Briefly, male Wistar rats were subjected to permanent bilateral common carotid artery occlusion (BCCAO) by surgery. After 4 weeks, the cognitive deficits were assessed using the Morris water maze and novel object recognition tests. The biochemical parameters of oxidative stress and inflammation were also assessed. Results: Rats in the BCCAO group showed cognitive deficits, accompanied by oxidonitrosative stress, neuroinflammation, and a reduction in brain-derived neurotrophic factor (BDNF) in the hippocampus region. Moreover, the acetylcholinesterase activity in the hippocampus was found to be increased in the BCCAO group compared to the sham group. The 4-week treatment with melatonin (10 mg/kg) and resveratrol (20 mg/kg) alone and in combination (melatonin 5 mg/kg and reseveratrol 10 mg/kg) caused a significant improvement in the cognitive deficits induced by BCCAO, accompanied by a reversal of oxidonitrosative stress, neuroinflammation, and BDNF depletion in the hippocampus region. Additionally, the treatment with melatonin and resveratrol significantly decreased acetylcholinesterase activity compared to in the BCCAO group. Melatonin and resveratrol ameliorated the BDNF expression of hippocampal protein. Conclusion: These results emphasize that coadministration of melatonin and resveratrol can be beneficial in BCCAO-induced vascular dementia through changes in BDNF expressions.

show abstract

On the antioxidant activity of melatonin

Cited by 119 publications

References 52 publications

Actions of Melatonin in the Reduction of Oxidative Stress

Actions of Melatonin in the Reduction of Oxidative Stress

Melatonin: reducing the toxicity and increasing the efficacy of drugs

Effect of Melatonin and Resveratrol against Memory Impairment and Hippocampal Damage in a Rat Model of Vascular Dementia

Contact Info

Product

Resources

About