On the Anti-Inflammatory Activity of Aminophylline

Sponge-induced exudate from the rat and saline extracts of normal rat liver and rat liver damaged in situ by dimethylnitrosamine have been assayed for putrescine, spermidine and spermine levels. The three physiological oligoamines have been examined for anti-inflammatory activity by the carrageenan-induced oedema rat model and spermidine and putrescine were found to be anti-inflammatory with putrescine being about ten times as active as spermidine. Putrescine was also anti-inflammatory in the adjuvant arthritic rat model. Thioacetamide and theophylline were also anti-inflammatory and theophylline doubled the level of putrescine in rat liver. It was concluded that putrescine was a potent anti-inflammatory factor in the inflammatory exudates and extracts examined.

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“…This result confirms a previous finding for this drug [27]. Thioacetamide suppressed oedema at 5 h by 75% (p < 0.001).…”

Section: Figuresupporting

confidence: 82%

“…This may explain why theophylline treatment at both 15 and 30 mg kg -~ depressed the inflammation to the same extent. The antiinflammatory action of theophylline is in agreement with previous findings [27]. …”

Section: Tablesupporting

confidence: 82%

Putrescine — a potent endogenous anti-inflammatory substance in inflammatory exudates

1983

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“…Catecholamines exert a similar 8-adrenoceptor mediated effect in the lungs, where they tend to oppose the bronchoconstrictor effects of histamine, bradykinin and 5-hydroxytryptamine (Collier, James & Piper, 1965;Piper, Collier & Vane, 1967). The ability of smooth muscle relaxant drugs to inhibit certain types of inflammation (McKinney & Lish, 1964;1966) might also be due to antagonism of endothelial contraction.…”

Section: Discussionmentioning

confidence: 99%

The anti‐inflammatory effect of catecholamines in the peritoneal cavity and hind paw of the mouse

Green

1972

British J Pharmacology

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Summary Carrageenin or 5‐hydroxytryptamine‐induced oedema of the mouse hind paw was antagonized by catecholamines acting on both α‐ and β‐adrenoceptors. Increased permeability of the mouse peritoneum induced by the local injection of acetic acid or pro‐inflammatory mediators was antagonized by catecholamines acting predominantly on β‐adrenoceptors. The anti‐inflammatory effect of catecholamines was due neither to hyper‐glycaemia nor to the release of adrenal cortical hormones.

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The antagonism between anti‐inflammatory drugs and substances that constrict veins

Northover

1967

J. Pathol.

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On the Anti-Inflammatory Activity of Aminophylline

Cited by 8 publications

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Putrescine — a potent endogenous anti-inflammatory substance in inflammatory exudates

Putrescine — a potent endogenous anti-inflammatory substance in inflammatory exudates

The anti‐inflammatory effect of catecholamines in the peritoneal cavity and hind paw of the mouse

The antagonism between anti‐inflammatory drugs and substances that constrict veins

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