On the analogy between forskolin and D-glucose

Abbadi, Mehdi; Morin, Christophe

doi:10.1016/s0960-894x(99)00270-x

Cited by 5 publications

(1 citation statement)

References 25 publications

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“…Many of the beneficial effects of C. forskohlii consumption have been attributed to the pharmacological actions of forskolin, a major diterpene isolated from the root of C. forskohlii . Forskolin increases cyclic adenosine monophosphate (cAMP) via activation of the enzyme adenylate cyclase by binding to the glucose transporter owing to the right ring of the Decalin portion of forskolin having structural similarity with alpha‐D‐galactose (Abbadi and Morin, ; Laurenza et al ., ). Enhanced lipolysis as a result of elevation of cAMP by forskolin resulted in the breakdown of stored fats in animal cells (Okuda et al ., ) and human fat cells (Allen et al ., ).…”

Section: Introductionmentioning

confidence: 99%

Dietary Coleus forskohlii extract generates dose‐related hepatotoxicity in mice

Virgona

Taki

Yamada

et al. 2012

J of Applied Toxicology

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Coleus forskohlii root extract (CFE) represented by its bioactive constituent 'forskolin' is popularly used as a natural weight-lowering product, but the association of its use with liver-related risks is very limited. In the present study, the effect of standardized CFE with 10% forskolin on liver function of mice was examined. Mice were given 0-5% CFE in an AIN93G-based diet for 3-5 weeks. Food intake, body weights, relative organ weights and liver marker enzymes [aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP)] combined with histophatological analysis were assessed. CFE (0-0.5%) only had minimal effects on food intake and body weight whereas a significant difference was observed in mice receiving the highest dose (5% CFE). The extract 0.05-5% dose-dependently decreased visceral fat weight by between 16% and 63%, and a dose-dependent several folds increase was observed in liver weights and plasma AST, ALT and ALP activities with quick onset apparent after only 1 week of 0.5% CFE intake. The hepatic effect persisted throughout the 3-weeks course but was restored towards normalization within 1 week after withdrawal of treatment. Liver histology of mice fed 0.5% CFE for 3 weeks showed hepatocyte hypertrophy and fat deposition. In contrast, none of the hepatic responses measured were altered when mice were given a diet containing pure forskolin alone at the dose corresponding to its content in 0.5% CFE. The present study clearly indicated that forskolin was not involved in the CFE-induced hepatotoxicity and was caused by other unidentified constituents in CFE which warrants further studies.

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Section: Introductionmentioning

confidence: 99%

Dietary Coleus forskohlii extract generates dose‐related hepatotoxicity in mice

Virgona

Taki

Yamada

et al. 2012

J of Applied Toxicology

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In situ proton NMR study of acetyl and formyl group migration in mono‐O‐acyl D‐glucose

Brecker

Mahut

Schwarz

et al. 2009

Magnetic Reson in Chemistry

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Acetyl and formyl group migration, mutarotation, and hydrolysis of mono-O-acylated glucose are studied by in situ 1D and 2D (1)H NMR spectroscopy. Alpha-D-glucosyl-1-acetate and alpha-D-glucosyl-1-formate serve as sole starting materials. They are generated in situ by configuration retaining glucosyltransfer from alpha-D-glucosyl-1-phosphate to formate and acetate, which is catalyzed by the Glu-237 --> Gln mutant of Leuconostoc mesenteroides sucrose phosphorylase. Temporary accumulated regio-isomeric mono-O-acyl D-glucoses are identified, characterized, and quantified directly from the reaction mixture. Time courses of the transformations give insight into pH dependence of acyl group migration and mutarotation as well as into the stability of various regioisomers.

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