On the Action of Mammalian Hormones

Factors influencing oestrogen-induced sensitization to acetylcholine of guinea-pig uterine artery

“…It has been suggested previously that this could be due to mediation of the sensitizing effect by an oestrogen other than oestradiol-17ß (Bell, 1973). Hechter & Halkerston (1964) drew attention to the fact that, while oestradiol-17ß is by far the most potent oestrogen in terms of uterotrophic activity, it is almost matched by oestriol in potency with regard to induction of uterine hyperaemia and water imbibition. In the sheep uterine artery the dilator potencies of oestradiol-17ß and oestriol are similar (Resnik, Killam, Battaglia, Makowski & Meschia, 1974).…”

Parathyroid hormone acutely increases polyphosphoinositides of the rabbit kidney cortex by a cycloheximide-sensitive process.

“…cAMP also increases adrenal PPI, and this increase is blocked by inhibitors of protein synthesis, e.g., puromycin and cycloheximide (CH) (12). Becuase of similarities between ACTH and PTH action in their respective target tissues (both hormones increase cAMP [5,13], Ca++ uptake [6,14], mitochondrial cytochrome P-450-mediated hydroxylations [2,15], and uptake of amino acids [3,16]), it seemed worthwhile to study effects of PTH on renal PPI. Our findings, herein reported, show that PTH, like ACTH, increases PPI in a target tissue by a CH-sensitive process.…”

The effects of the production of sodium depletion by peritoneal dialysis with 5% glucose on the volume and composition of the extracellular fluid of dogs

“…Some protection of extracellular potassium concentration was presumably provided by the reduction of e.c.f. volume; this would have been opposed by the increased passage of potassium into cells during the conversion of absorbed glucose to glycogen (Boen, 1964), and secondary to elevated levels of plasma insulin (Hechter & Halkerston, 1964).…”