On the Absorption of Vitamin D from the Skin

Hume, Eleanor Margaret; Lucas, Nathaniel Sampson; Smith, Hannah Henderson

doi:10.1042/bj0210362

Cited by 51 publications

(10 citation statements)

References 3 publications

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“…Vitamin D deficiency has become of increasing interest because of its association with many common disease processes and also because of an apparent increase in prevalence-it has been referred to as a world pandemic. 129 Humans have evolved to depend on the sun for their vitamin D requirements (wavelengths between 270 and 300 nm 130 ), and although some foods naturally contain vitamin D, foods that are fortified with vitamin D are often inadequate to satisfy vitamin D requirements. 131,132 It is the view of some individuals that recommendations for the avoidance of all sun exposure has put the world's population at risk of developing vitamin D deficiency.…”

Section: Role Of Dietmentioning

confidence: 99%

Ultraviolet Radiation and the Anterior Eye

Coroneo

2011

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

115

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The eye is on the one hand dependent on visible light energy and on the other hand can be damaged by these and the contiguous ultraviolet (UV) and infrared wavelengths. Diseases of the eye in which sunlight has been implicated have been termed the ophthalmohelioses, and these conditions pose a significant problem to the eye health of many communities. The ophthalmohelioses have a tremendous impact on patients' quality of life and have significant implications on the cost of health care. Although cataract is not entirely caused by insolation, it now seems certain that sunlight plays a contributory role-cataract extraction is one of the, if not the most, commonly performed surgical procedures in many societies. Pterygium, typically afflicting a younger population, adds a tremendous burden, both human and financial, in many countries. We review evidence that peripheral light focusing by the anterior eye to the sites of usual locations of pterygium and cataract plays a role in the pathogenesis of these conditions. Recognition of the light pathways involved with foci at stem cell niches has directed our investigations into inflammatory and matrix metalloproteinase-related pathophysiologic mechanisms. An understanding of the intracellular mechanisms involved has provided some insight into how medical treatments have been developed for the effective management of ocular surface squamous neoplasia. The concept of peripheral light focusing has also provided direction in the prevention of these diseases. This has resulted in improved sunglass design and the further development of UV-blocking contact lenses. With the development of ocular UV fluorescence photographic techniques, we have been able to demonstrate preclinical ocular surface evidence of solar damage. Evidence that diet may play a role in the development of certain conditions is reviewed. The conundrum of the public health message about solar exposure is also reviewed, and in this context, the potential role of vitamin D deficiency is summarized. The eye may play a role in the development of individualized assessment techniques of solar damage, perhaps allowing us to provide better advice to both individuals and populations.

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Section: Role Of Dietmentioning

confidence: 99%

Ultraviolet Radiation and the Anterior Eye

Coroneo

2011

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

115

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“…During sunlight exposure, the skin is penetrated by ultraviolet B photons by which pre-vitamin D3 is isomerized into vitamin D3 by the body heat [2]. Most people depended on the sun for the need for vitamin D but when they use sunscreen, ant-aging creams they block the effect of the sun and reduce their synthesis, other factors like their exposure time of the day, and the season, and latitude they all dramatically affect the skin pigment and disturbs synthesis of previtamin D3 [3]. It is necessary to update the evaluation of the positive effect of mild sunlight to make sure that all people take their need of vitamin D to gain health [4].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Impact on Human Health and Its Relation With Several Diseases

et al. 2018

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Vitamins are organic nutrients and substances that are needed for many biochemical functions. They are one of the six essential elements required for human life. Vitamin D is also known among the public as the Sunshine vitamin, as it is produced internally within the human body when exposed to sunlight and it is well known that the big majority of United Arab Emirates (UAE) population suffer from its deficiency.They are usually not found inside the body and therefore must be eaten from food or taken by supplements. Vitamin D that is obtained from diet or body synthesis when it is exposed to sufficient sunlight is biologically inactive without the enzymatic activation that converts it into its active form in the liver and kidney.Deficiency of vitamin D could lead to many troubling diseases such as depression including seasonal affective disorder, Parkinson’s disease, Alzheimer’s disease, Arthritis (gout, osteoarthritis, tendonitis), Osteoporosis, gum and teeth diseases, obesity, diabetes, heart diseases, metabolic syndromes, immunity related diseases (sclerosis, erythematosis), and cancer, which will be discussed in this review. The main objective of the current review is to evaluate the associations of vitamin D with the diverse health outcomes according to the latest studies done so far.

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“…[10][11][12][13] Photolysis of 7-dehydrocholesterol to previtamin D 3 in skin is dependent on UV radiation with a wavelength between 280 and 320 nm. [10][11][12][13] Photolysis of 7-dehydrocholesterol to previtamin D 3 in skin is dependent on UV radiation with a wavelength between 280 and 320 nm.…”

mentioning

confidence: 99%

Plasma 25-hydroxyvitamin D3 concentrations in Hermann's tortoises (Testudo hermanni) exposed to natural sunlight and two artificial ultraviolet radiation sources

Selleri¹,

Girolamo²

2012

ajvr

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Objective-To determine the effect of various UVB radiation sources on plasma 25-hydroxyvitamin D(3) concentrations in Hermann's tortoises (Testudo hermanni). Animals-18 healthy Hermann's tortoises. Procedures-Tortoises were exposed to sunlight in an outdoor enclosure located in the natural geographic range of Hermann's tortoises (n = 6 tortoises) or a self-ballasted mercury-vapor lamp (6) or fluorescent UVB-emitting lamp (6) in an indoor enclosure for 35 days. Plasma samples were obtained from each tortoise on the first (day 0) and last (day 35) days of the study, and concentrations of 25-hydroxyvitamin D(3) were determined. Amount of UVB radiation in enclosures was measured. Results-Mean ± SD plasma 25-hydroxyvitamin D(3) concentrations for tortoises exposed to the mercury-vapor and fluorescent lamps were significantly lower on day 35 (155.69 ± 80.71 nmol/L and 134.42 ± 51.42 nmol/L, respectively) than they were on day 0 (368.02 ± 119.34 nmol/L and 313.69 ± 109.54 nmol/L, respectively). Mean ± SD plasma 25-hydroxyvitamin D(3) concentration for tortoises exposed to sunlight did not differ significantly between days 0 (387.74 ± 114.56 nmol/L) and 35 (411.51 ± 189.75 nmol/L). Mean day 35 plasma 25-hydroxyvitamin D(3) concentration was significantly higher for tortoises exposed to sunlight versus those exposed to mercury-vapor or fluorescent lamps. Sunlight provided significantly more UVB radiation than did the mercury-vapor or fluorescent lamps. Conclusions and Clinical Relevance-Plasma 25-hydroxyvitamin D(3) concentrations differed between tortoises exposed to sunlight and those exposed to artificial UVB sources. Exposure to sunlight at a latitude similar to that of the natural geographic range is recommended for healthy and calcium-deficient tortoises.

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On the Absorption of Vitamin D from the Skin

Cited by 51 publications

References 3 publications

Ultraviolet Radiation and the Anterior Eye

Ultraviolet Radiation and the Anterior Eye

Vitamin D Impact on Human Health and Its Relation With Several Diseases

Plasma 25-hydroxyvitamin D3 concentrations in Hermann's tortoises (Testudo hermanni) exposed to natural sunlight and two artificial ultraviolet radiation sources

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