On the Ability of Ultrasound Parametric Perfusion Imaging to Predict the Area of Infarction in AcuteIschemic Stroke

Seidel, Günter; Cangür, Hakan; Meyer‐Wiethe, Karsten; Renault, Gilles; Herment, A.; Schindler, Angela; Kier, Christian

doi:10.1055/s-2006-927023

Cited by 19 publications

(23 citation statements)

References 15 publications

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“…It is expected that ultrasound contrast agents will be used increasingly in the evaluation of microcirculation, e.g., for perfusion studies (Seidel et al 2006;Claudon et al 2008). With the recent advances in ultrasound technology, however, for most applications this is not necessary.…”

Section: Specific Instrument Settings Using Echo Enhancersmentioning

confidence: 99%

Ultrasonography in Vascular Diagnosis

Schäberle

2011

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The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature.Cover design: eStudioCalamar, Fiqueres/Berlin

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Section: Specific Instrument Settings Using Echo Enhancersmentioning

confidence: 99%

Ultrasonography in Vascular Diagnosis

Schäberle

2011

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“…So far, TCS is routinely implemented into stroke workup for assessment of the vascular status and allows a sufficient display of intracerebral structures and pathologies . The additional use of ultrasound contrast media offers a better illustration not only of the cerebral arteries but also of the extent and localization of perfusion deficit in patients with acute stroke …”

Section: Discussionmentioning

confidence: 99%

“…6 Studies using transcranial perfusion sonography (TPS) were able to detect a perfusion deficit corresponding to the later infarction area in acute ischemic stroke. 7,8 Based on these study results, we hypothesized that a distinction of ICH and PHI is possible via a combination of TCS and TPS by detection of the hyperechogenic area associated with a larger perfusion deficit. According to our hypothesis, patients with PHI would show a relevant perfusion deficit around the hemorrhagic area, whereas patients with ICH would not.…”

Section: Introductionmentioning

confidence: 94%

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Transcranial Sonography to Differentiate Primary Intracerebral Hemorrhage from Cerebral Infarction with Hemorrhagic Transformation

Niesen

Schläger²,

Reinhard

et al. 2018

Journal of Neuroimaging

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“…The second‐generation ultrasound contrast agents (CA) have created new possibilities for non‐invasive quantification of tissue perfusion. Sulphur hexafluoride (SonoVue, Bracco S.P.A., Milan, Italy) is widely used for organ perfusion evaluation (liver, kidneys, brain) in adults . Sulphur hexafluoride has recently been approved for paediatric use in USA, but not yet in Europe.…”

Section: Introductionmentioning

confidence: 99%

Assessment of cerebral perfusion with contrast‐enhanced ultrasound during constriction of the neck mimicking malposition of the BD Odon Device™: a study in newborn piglets

Lange

Solberg

2017

BJOG

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Objective The BD Odon Device TM is a new instrument for operative vaginal birth with potential for preventing maternal, fetal and newborn morbidity/mortality during a complicated second stage of labour. The device is a plastic sleeve with an air chamber inflated around the baby's head which is gently pulled through the birth canal. The aim was to monitor changes in cerebral circulation during constriction of the neck to evaluate a risk of potential malposition of the device.Design Randomised prospective study.Population or sample Twelve newborn piglets.Methods The anaesthetised piglets were exposed to hypoxia until base excess was -20 mmol/l and/or mean arterial blood pressure had decreased to 20 mmHg. At reoxygenation, an air chamber was inflated around the neck to 300 mmHg and the piglets randomised into three groups: 10 (n = 5), 5 (n = 5) or 2 (n = 2) minutes' occlusion. Cerebral perfusion was evaluated with transcranial contrast-enhanced ultrasound at four time-points, and analysed in the carotid arteries, basal ganglia, cortex and whole brain. Statistical analysis used ANOVA, linear mixed model, Kruskal-Wallis H-test.Main outcome measures Perfusion parameters; peak intensity, time to peak intensity, upslope, mean transit time, area under the curve.Results The haemodynamic response was comparable between groups. Perfusion parameters showed a slight increase at end hypoxia followed by a decrease during occlusion, especially in the cortex (P = 0.00-0.2). After deflation, perfusion returned towards baseline values.Conclusions Simulation of malposition of the Odon Device was performed using a newborn hypoxic piglet model. Considerable compression of the neck vessels was applied, with only a moderate decrease in perfusion and with restoration of haemodynamics/ cerebral perfusion after decompression.Keywords Assisted vaginal birth, BD Odon Device TM , cerebral perfusion, contrast-enhanced ultrasound, hypoxia, newborn pig.Tweetable abstract Malposition of Odon Device TM in a piglet model revealed a reversible decrease in cerebral perfusion during neck constriction.Please cite this paper as: de Lange C, Saugstad OD, Solberg R. Assessment of cerebral perfusion with contrast-enhanced ultrasound during constriction of the neck mimicking malposition of the BD Odon Device TM : a study in newborn piglets. BJOG 2017; 124 (S4): 26-34.

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On the Ability of Ultrasound Parametric Perfusion Imaging to Predict the Area of Infarction in AcuteIschemic Stroke

Abstract: BHI can detect disturbed perfusion in acute hemispheric stroke. In their ability to predict the development of an infarction, intensity-based parameters and FAMIS were determined to have a high sensitivity, and TTP was found to have a high PPV and specificity.

Cited by 19 publications

References 15 publications

Ultrasonography in Vascular Diagnosis

Ultrasonography in Vascular Diagnosis

Transcranial Sonography to Differentiate Primary Intracerebral Hemorrhage from Cerebral Infarction with Hemorrhagic Transformation

Assessment of cerebral perfusion with contrast‐enhanced ultrasound during constriction of the neck mimicking malposition of the BD Odon Device™: a study in newborn piglets

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