A Fréchet space, X , with a sequence of generating seminorms { • k } ∞ k=1 is called tame in case there exists an increasing function σ : N → N, such that for every continuous linear operator T from X into itself, there exists an N 0 and C > 0 such thatThis property does not depend upon the choice of fundamental system of semi-norms for X and is a property of the Fréchet space X . In this paper we investigate tameness in the Fréchet spaces O(M ) of analytic functions on Stein manifolds M equipped with the compact open topology. Actually we will look into tameness in the more general class of nuclear Fréchet spaces with the properties DN and Ω of Vogt and then specialize to analytic function spaces. We will show that for a Stein manifold M , tameness of O(M ) is equivalent to the hyperconvexity of M .