In recent years, the studies of reliability properties of consecutive k-out-of-n structures have attracted a great impact of attention from both theoretical and practical approaches. In this paper, we have studied the reliability measures of a complex structure, which consists of two substructures namely, A and B handling by human operators. The substructure A is of the type 2-out-of-3:F (with unequal components), which is connected with the substructure B in series configuration. The complete structure can be failed due to the failure of any two components of substructure A, any component of A with failure of substructure B and due to human error. All failure and repair rates are assumed to be constant. The structure is analyzed by the usage of supplementary variable technique and Laplace transformation. Generalized expressions of state probabilities, availability and reliability of the structure, mean time to failure, cost analysis and sensitivity analysis are developed.