On Some Physiological Aspects of Ethanol Repercussion on Neural and Cardiorenal Functions

Guedes, Rubem Carlos Araújo; Paiva, Ana Maria de Alburquerque; Amâncio-dos-Santos, Ângela; Vieira‐Filho, Leucio D.; Paixão, Ana D.O.

doi:10.2174/187152409789630433

Cited by 3 publications

(2 citation statements)

References 115 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Otherwise, FA was not effective in reducing renal malondialdehyde (MDA) levels in those animals and preventing the architectural damages in the kidney, such as degeneration and tubular necrosis, swollen glomeruli, and infiltration of lymphocytes triggered by AZA. 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 …”

Section: Resultsmentioning

confidence: 99%

“… 47 Hostile conditions can compromise embryonic nephrogenesis and in turn, alter the glomerular filtration rate. 63 Albeit FA has not reverted some disorders associated with nephrogenesis, it is suggested that folate deficiency might impact this process through epigenetic modulation. 43 There are hypotheses that little availability of folate, B12 vitamin, and other nutrients affects the volume of the kidneys and decreases the nephrons number of the offspring, predisposing to chronic renal disease in adulthood, 45 64 it reinforcing the concept of fetal programming.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of Maternal Folic Acid Supplementation on Descendants' Kidney in Adulthood

Fernandes

Conde

Brasil

et al. 2023

Rev Bras Ginecol Obstet

View full text Add to dashboard Cite

Supplementation with folic acid (FA) during gestation has been recommended by medical society all over the world, but some studies have shown that intake of high folic acid diet may unleash damages to the descendants. Objectives: Describing the effects of maternal supplementation with FA during gestation on offspring's kidney at late life stages. Data Source: It is a systematic review by which were consulted the following databases: Medline, through Pubmed, Lilacs, and SciELO. The research was performed using the keywords “Folic acid”, “Gestation” and “Kidney”. Study Selection: Eight studies were regarded for this systematic review. Data Collection: Only studies that evaluated folic acid consumption during gestation and its effects exclusively on descendants' kidney at several phases of life were regarded. Results: Gestational FA intake did not change the renal volume, glomerular filtration rate and the expression of some essential genes in the kidney of puppies whose dams were supplemented with FA. Maternal consumption of double FA plus selenium diet was effective in preserving antioxidant enzymes activity in the kidney of descendants from mothers exposed to alcohol. FA supplementation decreased some gross anomalies in the puppies caused by teratogenic drug despite of had not been effective in preventing some renal architectural damages. Conclusion: FA supplementation did not cause renal toxicity; it exerted an antioxidant protective effect and mitigated some renal disorders caused by severe aggressions.

show abstract