Let G be a connected complex reductive group. A well known theorem of I. Losev's says that a smooth affine spherical G-variety X is uniquely determined by its weight monoid, which is the set of irreducible representations of G that occur in the coordinate ring of X. In this paper, we use the combinatorial theory of spherical varieties and a smoothness criterion of R. Camus to characterize the weight monoids of smooth affine spherical varieties.