On-skin glucose-biosensing and on-demand insulin-zinc hexamers delivery using microneedles for syringe-free diabetes management

Hsu, Wen‐Lin; Huang, Chiung-Yin; Hsu, Ying-Pei; Hwang, Tsong‐Long; Chang, Shwu Fen; Wang, Hay-Yan J.; Feng, Lin; Tzou, Shiow-Jyu; Wei, Kuo‐Chen; Yang, Hung-Wei

doi:10.1016/j.cej.2020.125536

Cited by 44 publications

(24 citation statements)

References 36 publications

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“…4 C, S2B). Drug release was recorded using an in vitro model based on 1% agarose gel [46] . The results showed that the dye loaded in the MNs could start releasing within 5 min ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Design and fabrication of r-hirudin loaded dissolving microneedle patch for minimally invasive and long-term treatment of thromboembolic disease

Xia

et al. 2022

Asian Journal of Pharmaceutical Sciences

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“…4 C, S2B). Drug release was recorded using an in vitro model based on 1% agarose gel [46] . The results showed that the dye loaded in the MNs could start releasing within 5 min ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Design and fabrication of r-hirudin loaded dissolving microneedle patch for minimally invasive and long-term treatment of thromboembolic disease

Xia

et al. 2022

Asian Journal of Pharmaceutical Sciences

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“…Quantitative analysis of glucose in human serum sample by measuring the colour intensity of the catalytic reaction was performed by using a software installed in smartphone. Based on these interesting findings, recent development of a non-invasive instrument-free glucose biosensor was reported by Yang’s group [ 238 ]. They fabricated glucose-biosensing microneedle patch (GBMP) consisting of GOx-conjugated MnO 2 / graphene oxide nanozymes (GOx-MnO 2 @GO) and swelling methacrylate gelatin (MeGel).…”

Section: Nanozymes For the Development Of Biosensors And Poc Devices Following Assured Criteriamentioning

confidence: 99%

“…Copyright 2018 Elsevier. c Schematic illustration of skin interstitial fluid (ISF) extraction using glucose-biosensing microneedle patch (GBMP) and the principle of colorimetric glucose detection using GOx-MnO2@GO as a colorimetric probe and smart phone-based app for quantitative analysis at hyperglycaemic condition [ 238 ]. Copyright 2020 Elsevier …”

Section: Nanozymes For the Development Of Biosensors And Poc Devices Following Assured Criteriamentioning

confidence: 99%

Nanozymes in Point-of-Care Diagnosis: An Emerging Futuristic Approach for Biosensing

et al. 2021

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Nanomaterial-based artificial enzymes (or nanozymes) have attracted great attention in the past few years owing to their capability not only to mimic functionality but also to overcome the inherent drawbacks of the natural enzymes. Numerous advantages of nanozymes such as diverse enzyme-mimicking activities, low cost, high stability, robustness, unique surface chemistry, and ease of surface tunability and biocompatibility have allowed their integration in a wide range of biosensing applications. Several metal, metal oxide, metal–organic framework-based nanozymes have been exploited for the development of biosensing systems, which present the potential for point-of-care analysis. To highlight recent progress in the field, in this review, more than 260 research articles are discussed systematically with suitable recent examples, elucidating the role of nanozymes to reinforce, miniaturize, and improve the performance of point-of-care diagnostics addressing the ASSURED (affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free and deliverable to the end user) criteria formulated by World Health Organization. The review reveals that many biosensing strategies such as electrochemical, colorimetric, fluorescent, and immunological sensors required to achieve the ASSURED standards can be implemented by using enzyme-mimicking activities of nanomaterials as signal producing components. However, basic system functionality is still lacking. Since the enzyme-mimicking properties of the nanomaterials are dictated by their size, shape, composition, surface charge, surface chemistry as well as external parameters such as pH or temperature, these factors play a crucial role in the design and function of nanozyme-based point-of-care diagnostics. Therefore, it requires a deliberate exertion to integrate various parameters for truly ASSURED solutions to be realized. This review also discusses possible limitations and research gaps to provide readers a brief scenario of the emerging role of nanozymes in state-of-the-art POC diagnosis system development for futuristic biosensing applications.

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“…Some studies have suggested more accurate monitoring through minimally invasive methods. 100–103 The Zhang team developed a glucose sensor with a micro-needle structure. 104 Glucose oxidase and a gold nanocoating were used to modify the polymer micro-needles.…”

Section: Glucose Lactate and Uric Acid Sensorsmentioning

confidence: 99%

Recent advances in flexible and wearable sensors for monitoring chemical molecules

Zhao

Teng

et al. 2022

Nanoscale

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On-skin glucose-biosensing and on-demand insulin-zinc hexamers delivery using microneedles for syringe-free diabetes management

Cited by 44 publications

References 36 publications

Design and fabrication of r-hirudin loaded dissolving microneedle patch for minimally invasive and long-term treatment of thromboembolic disease

Design and fabrication of r-hirudin loaded dissolving microneedle patch for minimally invasive and long-term treatment of thromboembolic disease

Nanozymes in Point-of-Care Diagnosis: An Emerging Futuristic Approach for Biosensing

Recent advances in flexible and wearable sensors for monitoring chemical molecules

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