On-site illicit-drug detection with an integrated near-infrared spectral sensor: A proof of concept

Kranenburg, Ruben F.; Ou, Fang; Ševo, Petar; Petruzzella, Maurangelo; Ridder, Renee de; Klinken, Anne van; Hakkel, Kaylee D.; Elst, Don M. J. van; Veldhoven, René van; Pagliano, Francesco; Asten, Arian C. van; Fiore, Andrea

doi:10.1016/j.talanta.2022.123441

Cited by 33 publications

(15 citation statements)

References 35 publications

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“…Kranenburg et al used a custom-built portable IR device with 16 sensors that was used to analyze drug samples stored in glass vials. 207 Amphetamine, cocaine, heroin, ketamine, 3,4methylenedioxymethamphetamine (MDMA), and methamphetamine from casework samples were all analyzed. An LDA model accurately identified 100% of the spectra in both the internally cross-validated training and external validation data sets.…”

Section: ■ Chemistry: Seized Drugs and Toxicologymentioning

confidence: 99%

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Innovative Vibrational Spectroscopy Research for Forensic Application

et al. 2023

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Section: ■ Chemistry: Seized Drugs and Toxicologymentioning

confidence: 99%

“…Kranenburg et al used a custom-built portable IR device with 16 sensors that was used to analyze drug samples stored in glass vials . Amphetamine, cocaine, heroin, ketamine, 3,4-methylenedioxymethamphetamine (MDMA), and methamphetamine from casework samples were all analyzed.…”

Section: Chemistry: Seized Drugs and Toxicologymentioning

confidence: 99%

Innovative Vibrational Spectroscopy Research for Forensic Application

et al. 2023

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“…It can be used for noninvasive on-site drug screening since it is simple to collect and can be easily used for the drug testing of drivers and workers. − Because drugs have such a short half-life in the human body, it is challenging to detect their presence. Analytical detection methods such as high-performance liquid chromatography, gas chromatography, mass spectrometry, ion mobility spectrometry, Raman spectroscopy, Fourier transform infrared spectroscopy, nuclear magnetic resonance, and X-ray diffractometry accurately detect illegal drugs in the system. Despite their high accuracy and specificity, they suffer from a lack of accessibility and portability due to high cost, the need for trained personnel, a time-consuming and complex procedure, and the necessity for sample preparation. , Miniaturization and affordability, including cost-effectiveness, portability, flexibility, ease of use without pretreatment, and high sensitivity, have accelerated the use of electrochemical-based biosensors for drug abuse detection in oral fluid .…”

Section: Introductionmentioning

confidence: 99%

Smart Multiplex Point-of-Care Platform for Simultaneous Drug Monitoring

Beduk

Bedük

Filho

et al. 2023

ACS Appl. Mater. Interfaces

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Recently, illicit drug use has become more widespread and is linked to problems with crime and public health. These drugs disrupt consciousness, affecting perceptions and feelings. Combining stimulants and depressants to suppress the effect of drugs has become the most common reason for drug overdose deaths. On-site platforms for illicitdrug detection have gained an important role in dealing, without any excess equipment, long process, and training, with drug abuse and drug trafficking. Consequently, the development of rapid, sensitive, noninvasive, and reliable multiplex drug-detecting platforms has become a major necessity. In this study, a multiplex laser-scribed graphene (LSG) sensing platform with one counter, one reference, and three working electrodes was developed for rapid and sensitive electrochemical detection of amphetamine (AMP), cocaine (COC), and benzodiazepine (BZD) simultaneously in saliva samples. The multidetection sensing system was combined with a custom-made potentiostat to achieve a complete point-of-care (POC) platform. Smartphone integration was achieved by a customized application to operate, display, and send data. To the best of our knowledge, this is the first multiplex LSG-based electrochemical platform designed for illicit-drug detection with a custom-made potentiostat device to build a complete POC platform. Each working electrode was optimized with standard solutions of AMP, COC, and BZD in the concentration range of 1.0 pg/mL−500 ng/mL. The detection limit of each illicit drug was calculated as 4.3 ng/mL for AMP, 9.7 ng/mL for BZD, and 9.0 ng/mL for COC. Healthy and MET (methamphetamine) patient saliva samples were used for the clinical study. The multiplex LSG sensor was able to detect target analytes in real saliva samples successfully. This multiplex detection device serves the role of a practical and affordable alternative to conventional drug-detection methods by combining multiple drug detections in one portable platform.

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“…However, most of the instruments mentioned above are too bulky to allow portability, and are not only expensive but also need time-consuming operation. Although several methods using handheld instruments have been developed for on-field drug analysis [ 14 , 15 , 16 ], research results in this area are limited and synthetic cathinone detection still requires sensitive and portable devices for rapid screening on-site.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of a Molecularly-Imprinted-Polymer-Based Graphene Oxide Nanocomposite for Electrochemical Sensing of New Psychoactive Substances

Jiang¹,

Wu²,

Huang

et al. 2023

Nanomaterials

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As new psychoactive substances (commonly known as “the third generation drugs”) have characteristics such as short-term emergence, rapid updating, and great social harmfulness, there is a large gap in the development of their detection methods. Herein, graphite oxide (GO) was first prepared and immobilized with a reversible addition-fragmentation chain transfer (RAFT) agent, then a new psychoactive substance (4-MEC) was chosen as a template, and then the surface RAFT polymerization of methacrylamide (MAAM) was carried out by using azobisisobutyronitrile (AIBN) as an initiator and divinylbenzene (DVB) as a cross-linker. After the removal of the embedded template, graphene oxide modified by molecularly imprinted polymers (GO-MIPs) was finally obtained. Owing to the specific imprinted cavities for 4-MEC, the satisfactory selectivity and stability of the GO-MIP nanocomposite have been demonstrated. The GO-MIP nanocomposite was then used to fabricate the electrochemical sensor, which displayed a high selectivity in detecting 4-MEC over a linear concentration range between 5 and 60 μg mL−1 with a detection limit of 0.438 μg mL−1. As a result, the GO-MIPs sensor developed an accurate, efficient, convenient, and sensitive method for public security departments to detect illicit drugs and new psychoactive substances.

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On-site illicit-drug detection with an integrated near-infrared spectral sensor: A proof of concept

Cited by 33 publications

References 35 publications

Innovative Vibrational Spectroscopy Research for Forensic Application

Innovative Vibrational Spectroscopy Research for Forensic Application

Smart Multiplex Point-of-Care Platform for Simultaneous Drug Monitoring

Fabrication of a Molecularly-Imprinted-Polymer-Based Graphene Oxide Nanocomposite for Electrochemical Sensing of New Psychoactive Substances

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