On serotonin, psychedelics, entactogens and psychoplastogens in depression, anxiety, post-traumatic stress, and related disorders.
Daniel Hoyer
Abstract:There is controversy about a causal role of serotonin (5-HT) in
depression, some arguing that there is no proof for impaired brain 5-HT
function in depressed patients. Major depressive disorder comes with
multiple endophenotypes; not surprisingly classical antidepressants
(tricyclics, MAO inhibitors, SSRIs, SNRIs) are not universally
effective. Most antidepressants target the 5-HT system, partially if not
exclusively, but treatment-resistant depression (TRD) remains a major
issue. The most recent and heavily i… Show more
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