On Seeing Yellow

Simunovic, Matthew P.

doi:10.1001/archophthalmol.2011.1642

Cited by 16 publications

(10 citation statements)

References 84 publications

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“…[ 43 ] As such, inferences of neuronal cytocompatibility from the viability of secondary cultured cell lines do not infer compatibility and support of neuronal cells. Cell death and cell survival mechanisms can even vary between different types of neuron, [ 45 ] and selection of a biological tissue source which matches the target tissue of the proposed therapeutic application is critical for its application. The present work distinguishes itself from previously published in vitro organic semiconductor biocompatibility literature by choice of both assessment methodology and tissue source.…”

Section: Discussionmentioning

confidence: 99%

Design Parameters and Human Biocompatibility Assessment Protocols for Organic Semiconducting Neural Interfaces: Toward a Printed Artificial Retina with Color Vision

Sherwood

Crovador

Posar

et al. 2023

Adv Materials Inter

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Organic semiconductors have emerged as promising neural interfacing materials due to their innate biocompatibility, soft mechanical properties, and mixed electron/ion conduction. One exciting application is their use as artificial photosensors for retinal prostheses via optically induced neuromodulation. In this study, the optoelectronic and neural interfacing properties of six organic semiconductor polymers and small molecules, split into donor/acceptor pairs that form promising candidates for a trichromatic artificial retina that closely mimics the native response of the human eye are presented. The biocompatibility of these materials using primary human retinal cell cultures by systematic measurement of both cell viability and morphological analysis of retinal ganglion cell neurite elongation over time is investigated. Comparable cell viability between human retinal cell cultures established on all the organic semiconductors and a glass control, which is a standard measurement for biocompatibility in materials science is observed. In contrast, differences in the morphological biocompatibility between the organic semiconductor materials and glass control are detected by analyzing neurite elongation with specific immunomarkers. The difference in the two results has implications for the future assessment of material biocompatibility for bioelectronics, and optimal methodology for assessing morphological biocompatibility in neural interface devices is discussed.

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Section: Discussionmentioning

confidence: 99%

Design Parameters and Human Biocompatibility Assessment Protocols for Organic Semiconducting Neural Interfaces: Toward a Printed Artificial Retina with Color Vision

Sherwood

Crovador

Posar

et al. 2023

Adv Materials Inter

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“…Спектр поглощения катарактального хрусталика в видимой области в основном определяется пигментами, которые получаются из аминокислоты триптофан и накапливаются с возрастом и при катаракте [24][25][26]. В ближней ИК области спектр поглощения хрусталика определяется содержащейся в нем свободной и связанной водой -пики поглощения в окрестностях 1450 и 1950 nm.…”

Section: результаты и обсуждениеunclassified

Оптические свойства in vitro катарактальных хрусталиков глаза человека в видимом и ближнем ИК диапазонах-=SUP=-*-=/SUP=-

Беликов¹,

Загорулько²,

Smirnov³

et al. 2019

Журнал Технической Физики

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Spectral dependences of absorption coefficient, scattering coefficient, anisotropy factor and reduced scattering coefficient for in vitro human eye lenses of different cataract type are investigated. The spectra of absorption coefficient and reduced scattering coefficient were obtained for the spectral range 400-2300 nm, and the spectra of scattering coefficient and scattering anisotropy factor - for the spectral range 400-1800 nm. The regions of wavelengths within which the spectra of the studied optical characteristics of the human eye lens are not statistically significantly different for samples with different stages of cataract maturity and, conversely, within which they are statistically significantly different, are determined.

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“…The normal human crystalline lens absorbs ultraviolet (UV; wavelength: 10-400 nm) and harmful short wavelengths in visible electromagnetic radiation, namely blue light (wavelength: 400-495 nm) [11]. Age-related cataracts present with a yellow-brownish discoloration, which indicates an accumulation of chromophores that preferentially absorb short wavelengths in the visible spectrum [12]; the discoloration predominantly reduces the input of short wavelength light and reduces the light input by more than 70% [13].…”

Section: Introductionmentioning

confidence: 99%

Effects of ultraviolet and blue-light filtering on sleep: a meta-analysis of controlled trials and studies on cataract patients

Lee

Loh

Kuo

et al. 2020

Eye

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Purpose Two types of intraocular lenses (IOLs), namely ultraviolet-filtering IOL (UVF-IOL) and blue-light-filtering IOL (BF-IOL), are used to replace the aging lens in cataract patients. This provides a clinical scenario to investigate the BF and UVF effects on circadian rhythm. We revisited this topic and conducted an updated meta-analysis investigating the effects of UVF-IOL and BF-IOL on sleep quality. Methods A literature search was conducted using the PubMed, Embase, and Cochrane Library databases, and finally, four randomized controlled trials, one nonrandomized controlled study, and two cohort studies were included in this meta-analysis. ResultsThe fixed-effect model revealed a significantly larger sleep quality improvement in the UVF-IOL group than in the BF-IOL group (standard mean difference [SMD] = 0.10, 95% confidence interval [CI]: 0.00-0.21) at 3-8 weeks but not 7-12 months after IOL implantation (SMD = 0.03, 95% CI: −0.08 to 0.13). The random effects model revealed no difference between groups at 3-8 weeks (SMD = 0.16, 95% CI: −0.07 to 0.39) and 7-12 months (SMD = 0.03, 95% CI: −0.08 to 0.13) after IOL implantation. Conclusions Our study found some weak evidence supporting that UVF-IOL implantation demonstrated a greater improvement in subjective sleep quality than the BF-IOL implantation only in a shorter period but not in a longer period. More trials should be conducted before further recommendations. Nevertheless, our study provides some insights into the effects of short wavelength electromagnetic radiation on the circadian rhythm. PROSPERO registration number: CRD42019128832.

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On Seeing Yellow

Cited by 16 publications

References 84 publications

Design Parameters and Human Biocompatibility Assessment Protocols for Organic Semiconducting Neural Interfaces: Toward a Printed Artificial Retina with Color Vision

Design Parameters and Human Biocompatibility Assessment Protocols for Organic Semiconducting Neural Interfaces: Toward a Printed Artificial Retina with Color Vision

Оптические свойства in vitro катарактальных хрусталиков глаза человека в видимом и ближнем ИК диапазонах-=SUP=-*-=/SUP=-

Effects of ultraviolet and blue-light filtering on sleep: a meta-analysis of controlled trials and studies on cataract patients

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