On prioritising global health’s triple crisis of sepsis, COVID-19 and antimicrobial resistance: a mixed-methods study from Malawi

Abstract

Sepsis causes 20% of global deaths, particularly among children and vulnerable populations living in developing countries. This study investigated how sepsis is prioritised in Malawi’s health system to inform health policy. In this mixed-methods study, twenty multisectoral stakeholders were qualitatively interviewed and asked to quantitatively rate the likelihood of sepsis-related medium-term policy outcomes being realised. Respondents indicated that sepsis is not prioritised in Malawi due to a lack of local sepsis-related evidence and policies. However, they highlighted strong linkages between sepsis and maternal health, antimicrobial resistance and COVID-19, which are already existing national priorities, and offers opportunities for sepsis researchers as policy entrepreneurs. To address the burden of sepsis, we recommend that funding should be channelled to the generation of local evidence, evidence uptake, procurement of resources and treatment of sepsis cases, development of appropriate indicators for sepsis, adherence to infection prevention and control measures, and antimicrobial stewardship.

The Construction Path and Protection Measures of Wetland Park from the Perspective of National Participation in the New Era

“…InVEST water yield model is based on the principle of water balance, combined with climate, topography, hydrology, land use type [10], soil characteristics, and vegetation available water parameters through the model calculation to get the basin water yield as shown in Figure 1.…”

“…Formula ( 9) is a linear distance decay function, and formula (10) is an exponential distance decay function. d xy is the linear distance between the grid x and y; d r max is the maximum range of the threat factor r.…”

Vitamin D-Binding Protein and the Role of its Gene Polymorphisms in the Mortality of Sepsis Patients

“…This situation can cause organ damage, organ failure, and even mortality in patients ( 2 ). Sepsis is a significant global health problem, with high mortality rates worldwide ( 3 , 4 ). Although many factors can influence the development of sepsis and patient outcomes, recent studies have shown that genetic polymorphisms in the immune system and vitamin D metabolism can contribute to the variability of patient response to sepsis ( 5 , 6 ).…”

Epidemiologic features of neonatal sepsis and its COVID-19 associated temporal patterns in Jimma Medical Center, Ethiopia: A Joinpoint regression analysis

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