In this paper, we first define the vector product in Minkowski space $\mathbb{R}_{4}^{7}$, which is identified with the space of spatial split-octonions. Next, we derive the $G_{2}-$ frame formulae for a seven dimensional Minkowski curve by using the spatial split-octonions and the vector product. We show that Frenet–Serret formulas are satisfied for a spatial split octonionic curve. We obtain the congruence of two spatial split octonionic curves and give relationship between the $G_{2}-$ frame and Frenet–Serret frame. Furthermore, we present the Frenet–Serret frame with split octonions in $\mathbb{R}_{4}^{8}$. Finally, we give illustrative examples with Matlab codes.