On Phosphates and Phosphoric Acid as Dietary Factors in the Calcium Balance of Man

Malm, Ole J.

doi:10.3109/00365515309093516

Cited by 55 publications

(12 citation statements)

References 10 publications

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“…Furthermore, a decrease in phosphorus intake would I intake. It has been shown that high phosphorus intake will decrease the urinary excretion of calcium in normal subjects (21,22). The lack of any increase in urine calcium excretion in K. B. may have been due to this effect.…”

Section: Resultsmentioning

confidence: 99%

Dietary perturbation of calcium metabolism in normal man: compartmental analysis

Phang¹,

Berman²,

Finerman³

et al. 1969

J. Clin. Invest.

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A B S T R A C T The effect of dietary calcium intake on calcium metabolism was studied in eight normal volunteers by multicompartmental analysis of radiocalcium and balance data. In paired studies of six normal subjects on normal and high or low calcium intakes, necessary and sufficient criteria were used to determine changes in calcium metabolic parameters produced by alterations in dietary calcium. These changes involved gastrointestinal calcium absorption rate, renal and endogenous fecal rate constants, and bone resorption rate. Bone accretion rate and compartment sizes need not change between the paired studies. The changes of parameters involving kidney, gut, and bone were in a direction to support calcium homeostasis and were compatible with the pattern of changes produced by parathyroid hormone. However, the source of the stimulus for hormone secretion was not apparent since plasma calcium concentrations showed no significant difference between paired studies. The implications of these findings relative to control of hormone secretion, calcium regulatory mechanisms, and metabolic bone disease are discussed. INTRODUCTIONThe clinical significance of dietary calcium intake is well recognized. High or low calcium dietary intakes have been included in the therapeutic regimen for a number of

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Section: Resultsmentioning

confidence: 99%

Dietary perturbation of calcium metabolism in normal man: compartmental analysis

Phang¹,

Berman²,

Finerman³

et al. 1969

J. Clin. Invest.

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“…group received the intravenous injection, while the I.V. group received the isotope orally.7 This was done to minimize the effect of periodic or seasonal variations (6,14) and to use each individual as his own control. Preliminary tests had shown that one month after the administration of 0.7 /Ac Cae, the level of Ca' in the blood and in the excreta was no longer measurable.…”

Section: Material Design and Methodsmentioning

confidence: 99%

“…Although this point has been studied by several investigators (2)(3)(4)(5), there is considerable disagreement on the significance of the fecal route for calcium excretion in man. Thus Malm (6) has observed that different individuals may exhibit pronounced variations in the fecal calcium excretion and has suggested that extended observations be made on each proposed test subject. Since this approach is not practical-in many cases, it seemed desirable to establish the significance of the endogenous calcium output in the feces under our experimental conditions.…”

mentioning

confidence: 99%

Studies in Calcium Metabolism. The Fate of Intravenously Injected Radiocalcium in Human Beings 123

Bronner¹,

Harris²,

Maletskos³

et al. 1956

J. Clin. Invest.

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In the course of studies on the effect of phytates on calcium uptake in man (1) it became necessary to determine the extent to which endogenous calcium in the feces might contribute to the calcium balance. Although this point has been studied by several investigators (2-5), there is considerable disagreement on the significance of the fecal route for calcium excretion in man. Thus Malm (6) has observed that different individuals may exhibit pronounced variations in the fecal calcium excretion and has suggested that extended observations be made on each proposed test subject. Since this approach is not practical-in many cases, it seemed desirable to establish the significance of the endogenous calcium output in the feces under our experimental conditions.5The method chosen for investigation was to inject radiocalcium (Ca45) intravenously and to de-termine its concentration in the serum, urine and feces during several days. Such carried out in animals (7-10), but few such data are available for man (11-13). MATERIAL, DESIGN AND METHODSSubjects. Nine adolescent boys, institutionalized for mental inadequacy, but otherwise normal,6 served in the first study (Experiments A and B). In a later experiment (Experiment C), one individual (No. 57) was selected for intensive study. He was a spastic, but neither clinical nor laboratory examinations revealed any abnormalities in his mineral metabolism. The boys ranged in age from 10.9 to 15.7 years, with mean and median ages of 12.6 years. Their height ranged from 124 to 160 cm. with mean and median heights of 142 cm. Their weight ranged from 29.8 to 44.5 kgm., with a mean weight of 35.6 kgm., and a median weight of 36.0 kgm. The mental age of the boys averaged 7.2 years, (median: 7.2 years) and ranged from 5.8 to 9.2 years.The young male adult in Experiment C was 21 years old, weighed 51.4 kgm. and had a mental age of 10.0 years.Design. The subjects (Experiments A and B) were divided into two groups. One group (I.V.) was given the Cae intravenously, while the other group (P.O.) received Cae by mouth. One month later, the P.O. group received the intravenous injection, while the I.V. group received the isotope orally.7 This was done to minimize the effect of periodic or seasonal variations (6,14) and to use each individual as his own control. Preliminary tests had shown that one month after the administration of 0.7 /Ac Cae, the level of Ca' in the blood and in the excreta was no longer measurable. Two years later (Experiment C), one individual was studied intensively 6All of the subjects were under medical care and observation during their usually indefinite institutionalization. They were selected on the basis of clinical examination. Roentgenographs of the chest, knees, hands, skull and spine of six subjects (Nos. 10,11,13,14,15,16) were evaluated by an experienced roentgenologist, who concluded that they did not deviate from the normal range with respect to calcification.7The results on the study with ingested Ca will be presented elsewhere. Methods of analysis for Ca' an...

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“…The effect of very high phosphorus to calcium dietary ratios has not been studied in detail; most of the studies performed with high phosphorus intake have been limited to calcium-phosphorus ratios of 1:3 to 1:5 and have shown no effect of the dietary phosphorus on calcium intake in the presence of normal renal function [2,11,18,27]. The effect of calcium phosphorus ratios of 1 : 30 and 1 : 40, such as was documented, is unknown.…”

Section: Combined Decrease Absorption and Decreased Dietary Calciummentioning

confidence: 99%

Nutritional and metabolic bone disease in a zoological population

et al. 1976

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Abstract. The radiologic survey technique used atthe National Zoological Park has disclosed many cases of nutritional and metabolic bone disease of various types. This communication discusses calcium deficiency states seen in lion cubs associated with a meat diet, the increased need for calcium noted in egg-laying lizards, problems found in New World monkeys, antelopes (due to selenium and/or vitamin E deficiency), hypervitaminosis D, and lead poisoning noted in young primates. In all of these diagnoses, the use of routine radiographic studies has been extremely helpful, first in detecting that a bone or soft tissue abnormality is present, and then in the differential diagnosis of the etiology of this abnormality. As more is learned of the necessary nutriments for exotic species kept in captivity, it is expected that the nutritional disturbances described in this article will be seen with decreasing frequency.

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On Phosphates and Phosphoric Acid as Dietary Factors in the Calcium Balance of Man

Cited by 55 publications

References 10 publications

Dietary perturbation of calcium metabolism in normal man: compartmental analysis

Dietary perturbation of calcium metabolism in normal man: compartmental analysis

Studies in Calcium Metabolism. The Fate of Intravenously Injected Radiocalcium in Human Beings 123

Nutritional and metabolic bone disease in a zoological population

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