“…Indeed, other techniques, such as median nerve stimulation (MNS) that target the sensory system, can have a significant impact on motor cortex plasticity (Lai et al, 2016). The cortical and subcortical effects of MNS are thought to be mediated by bottom-up mechanisms, namely by a mechanism of coactivation that can trigger activation of the primary and secondary somatosensory areas (Hodzic, 2004), as well as the insula (Ferretti et al, 2007;Hodzic, 2004;Ibanez et al, 1995), and other cortical areas (Golaszewski et al, 2004;Manita et al, 2015;Wu, Van Gelderen, Hanakawa, Yaseen, & Cohen, 2005). Moreover, it has already been shown that the motor cortex and the sensory cortex can be comodulated by peripheral electric stimulation (Schabrun, Ridding, Galea, Hodges, & Chipchase, 2012) and that this sensorimotor integration is crucial for the acquisition and performance of motor skills (Arce-McShane, Ross, Takahashi, Sessle, & Hatsopoulos, 2016).…”