On/Off‐Switchable Zipper‐Like Bioelectronics on a Graphene Interface

Acetylene-sourced CVD-synthesised catalytically active graphene for electrochemical biosensing

“…Due to the outstanding electromechanical properties of graphene, which is capable of more than 20% elastic deformation without the perturbation of its electrical properties, graphene is rapidly becoming a viable alternative for low-cost bioelectronic device production (Chun et al, 2014;Parlak et al, 2014). Recent studies on the electrocatalytic activity of graphene have focused on the use of graphene oxide (GO) or reduced graphene oxide (rGO) (Ashaduzzaman et al, 2015;Kang et al, 2010;Shao et al, 2010); however the insertion of oxygenated functional groups to improve the hydrophilicity of the material causes a considerable reduction in the electronic transport properties of the graphene (Hu and Su, 2013).…”

pH-induced on/off-switchable graphene bioelectronics

“…[1][2][3][4][5][6][7] The integration of stimuli-responsive interfaces in these devices allows their operation as electrochemical gates, switching on and off or tuning the rate of the interfacial reaction to control and regulate mass transport, adhesive and, more importantly, electrochemical properties. [8][9][10][11][12][13] Herein, we aim to address the design and development of pH-encoded bio-catalysis by employing pH-responsive poly(4-vinyl pyridine) (P4VP) graphene oxide bio-interfaces ( pH Gr) to control and regulate enzyme-based molecular interaction.…”

Light‐Triggered Switchable Graphene–Polymer Hybrid Bioelectronics

“…After that the surface was activated by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and n-hydroxysulfosuccinimide (NHS) solution ([EDC] = [NHS] = 5 × 10 −3 M ) which was prepared with cold water and then equilibrated for 2 h at RT. [ 2 ] The resulting succinimide ester-terminated surface was rinsed with water and dried under a stream of nitrogen. Then graphene-based bioconjugate solution (15 µL) was dropped onto activated GCE and dried for 8 h at 4 °C.…”

“…[ 1 ] The development of switchable and/or tunable interfaces on 2D surfaces endowed with desirable functionalities, and incorporation of these interfaces into biodevices has been emerging as a topical area. [ 2,3 ] Despite the remarkable rate of progress exhibited by bioelectronic devices in combination with nanotechnology, they still cannot match the effi ciency of biological systems to carry out molecular recognition, catalyze chemical reactions, and respond and adapt to environmental cues. [ 4 ] Therefore, the advancement of biointerfaces by the synergistic combination of material and biological science provides an excellent opportunity to create hybrid bioelectronic devices, which could enhance electronic functionality by mimicking natural environments.…”