“On-off” SERS sensor triggered by IDO for non-interference and ultrasensitive quantitative detection of IDO

Fan, Min; She, Qiutian; You, Ruiyun; Huang, Yikai; Su, Hongjian; Lu, Yue

doi:10.1016/j.snb.2021.130166

Cited by 16 publications

(3 citation statements)

References 40 publications

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“…This enhancement allows for the detection of trace amounts of molecules, including biomarkers associated with cancer. For example, the SERS biosensor can detect Indoleamine-2,3-dioxygenase (IDO), which is related to cancer [36]. As shown in Fig.…”

Section: Raman-based Biosensorsmentioning

confidence: 99%

Fiber-Optic Biosensors for Cancer Theranostics: From in Vitro to in Vivo

Jin,

Xu,

Cao

et al. 2024

Photonic Sens

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Cancer has been one of the most serious diseases, resulting in more than 10 million deaths every year. Fiber-optic sensors have great potential for diagnosing and treating cancer due to their flexibility, precise positioning, real-time monitoring, and minimally invasive characteristics. Compared to traditional central laboratory examination, fiber-optic biosensors can provide high sensitivity, miniaturization, and versatility, which feature the point-of-care diagnostic capability. Herein, we focus on recent advances in fiber-optic biosensors for cancer theranostics. It is primarily concerned with advancements in the design of various fiber sensing approaches, fiber cancer sensing, and therapy sensors. With fiber-optic biosensors, cancer marker detection, cancerous cell differentiation, ex vivo tumor model validation, and in vivo tumor detection can be achieved. And the medical fiber also can be used to provide photothermal therapy, photodynamic therapy, and combination therapy for solid tumors. Additionally, cancer sensing and therapy can be integrated into the fiber, which demonstrates the multiplexing capabilities of fiber-optic biosensors. Lastly, we systematically summarize the fiber biosensor applications from in vitro to in vivo, and conclude with the challenges in development and prospects.

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Section: Raman-based Biosensorsmentioning

confidence: 99%

Fiber-Optic Biosensors for Cancer Theranostics: From in Vitro to in Vivo

Jin,

Xu,

Cao

et al. 2024

Photonic Sens

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“…Preparation of Au@4MBN@Ag NPs Au@4MBN@Ag NPs were prepared using a Raman reporter (i.e., 4MBN) as an anchor to guide the deposition of Ag atoms around the surface of Au cores. 28 The Au core was synthesized by the citrate reduction of HAuCl 4 . Briefly, 100 mL of 0.01 wt% HAuCl 4 was first boiled, followed by rapid addition of 2 mL of 1 wt% Na 3 Ct.…”

Section: Synthesis Of Gold Nanorods With Different Aspect Ratiosmentioning

confidence: 99%

Early detection of lung cancer via biointerference-free, target microRNA-triggered core–satellite nanocomposites

Chen

Wang

et al. 2022

Nanoscale

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“…At the same time, the Au@MBN@Ag NPs core-shell structure was used. A unique internal standard molecule, MBN, has a unique characteristic peak at 2228 cm −1 corresponding to the ν (C≡N) stretch mode, which can avoid the interference of molecular bio-regional signals (<1800 cm −1 ) [24]. Therefore, with the help of MBN as an internal standard molecule, the quantitative determination of tyrosine and urea was realized by the internal standard calibration method.…”

Section: Introductionmentioning

confidence: 99%

An Endoscope-like SERS Probe Based on the Focusing Effect of Silica Nanospheres for Tyrosine and Urea Detection in Sweat

et al. 2022

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In this work, we developed a new type of SERS probe, which was composed of glass-SiO2-Au@MBN@Ag nanoparticles (NPs) three-dimensional Surface-enhanced Raman spectroscopy (SERS) substrate. When the laser passed through the quartz glass sheet, on the one hand, the SiO2 NPs supporting the Au@MBN@Ag NPs increase the roughness of the substrate surface, resulting in a large number of hot spots among nanoparticles. On the other hand, based on the focusing effect of silicon dioxide nanospheres, the laser can better focus on the surface of nanoparticles in the inverted SERS probe, thus showing better SERS enhancement. Furthermore, the Au@MBN@Ag NPs core-shell structure was used with 4-mercaptobenzoonitrile (MBN) as an internal standard molecule, and the quantitative determination of tyrosine and urea was realized by internal standard correction method. The standard working curves of the two had good linear correlation with R2 above 0.9555. The detection limits of tyrosine and urea were in the range of 2.85 × 10−10 M~7.54 × 10−6 M, which confirms that this design can be used for quantitative and specific detection of biological molecules, demonstrating great practical significance for the research of diseases such as skin lesions and endocrine disorders.

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“On-off” SERS sensor triggered by IDO for non-interference and ultrasensitive quantitative detection of IDO

Cited by 16 publications

References 40 publications

Fiber-Optic Biosensors for Cancer Theranostics: From in Vitro to in Vivo

Fiber-Optic Biosensors for Cancer Theranostics: From in Vitro to in Vivo

Early detection of lung cancer via biointerference-free, target microRNA-triggered core–satellite nanocomposites

An Endoscope-like SERS Probe Based on the Focusing Effect of Silica Nanospheres for Tyrosine and Urea Detection in Sweat

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