On/off fluorescence emission induced by encapsulation, exchange and reversible encapsulation of a BODIPY-guest in self-assembled organometallic cages

Gou, Xing‐Xing; Peng, Jiaxin; Das, Rajorshi; Wang, Yao‐Yu; Han, Ying‐Feng

doi:10.1039/c8dt05103h

Cited by 19 publications

(13 citation statements)

References 58 publications

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“…In addition, the cell imaging results of Au 4 (2)Cl 4 and [Ag 4 (2) 2 ](OTf) 4 show that they both have potential as bioimaging agents, but the fluorescence intensity and cell uptake efficiency are lower than [Au 4 (2) 2 ](OTf) 4 (Supporting Information Figures S33 and S34). The same cell imaging experiments were also performed in human normal hepatocyte (L-02) cells, and the results show that only weak blue fluorescence and a negligible colocalization ratio (<10%) were observed in L-02 cells, indicating that they are highly specific for cancer cell imaging (Figure 5 and Supporting Information Figures S33-S35).…”

Section: Mechanochromic Propertiesmentioning

confidence: 99%

“…Stimuli-responsive luminescence supramolecular materials, materials that respond to light, pressure, temperature, or pH value, are of great interest owing to their appealing architectures 1-3 and widespread applications across many different fields. [4][5][6][7][8][9][10][11][12] The controllable fabrication of such materials and structures with high photostability, facile tunability, and good solubility in common organic solvents remains one of the current challenges in exploring the aforementioned applications. 13,14 Traditional fluorophores usually suffer from aggregation-caused quenching (ACQ) in the solid state or form colloidal aggregates and exhibit the heavy atom effect when coordinated with transition metals.…”

Section: Introductionmentioning

confidence: 99%

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Multistimuli-Responsive Fluorescent Organometallic Assemblies Based on Mesoionic Carbene-Decorated Tetraphenylethene Ligands and Their Applications in Cell Imaging

Yang

et al. 2022

CCS Chem

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The controllable construction of light-emitting organometallic supramolecular materials integrating stimulus responses and biological applications is still a major challenge today. In this work, emissive organometallic assemblies based on Ag I /Au I and mesoionic carbene-decorated tetraphenylethene (MIC-TPE) ligands have been synthesized and characterized. Photophysical studies showed that these organometallic assemblies [M 4 (2) 2 ](OTf) 4 not only fluoresce in various dilute solutions, resulting from the rigidification of MIC-TPE ligands upon complexation, but also show tunable fluorescence wavelengths and intensity behaviors in mixed solvent systems and at varying temperatures while in solution, and mechanical pressure stimulus-responsive fluorescent features in the solid state. Furthermore, the organometallic cages [M 4 (2) 2 ](OTf) 4 (M = Ag and Au) were successfully employed for cell imaging and showed the potential of anticancer activity, making them promising candidates for cancer theranostics. This work provides a simple and efficient method to prepare highly emissive and stimulus-responsive organometallic materials and paves the way for related biological applications such as cancer cell imaging and targeted therapy.

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Section: Mechanochromic Propertiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multistimuli-Responsive Fluorescent Organometallic Assemblies Based on Mesoionic Carbene-Decorated Tetraphenylethene Ligands and Their Applications in Cell Imaging

Yang

et al. 2022

CCS Chem

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“…The binding properties of coordination cages 1 − 9 in solution have been tailored to species ranging from gases 10 − 22 to heavy metals, 23 and neutral 24 − 28 and charged 29 − 34 compounds. A cage dissolved in one fluid phase is capable of extracting a guest from another immiscible one, without crossing the phase barrier.…”

Section: Introductionmentioning

confidence: 99%

Coordination Cages Selectively Transport Molecular Cargoes Across Liquid Membranes

et al. 2021

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Chemical purifications are critical processes across many industries, requiring 10–15% of humanity’s global energy budget. Coordination cages are able to catch and release guest molecules based upon their size and shape, providing a new technological basis for achieving chemical separation. Here, we show that aqueous solutions of Fe II 4 L 6 and Co II 4 L 4 cages can be used as liquid membranes. Selective transport of complex hydrocarbons across these membranes enabled the separation of target compounds from mixtures under ambient conditions. The kinetics of cage-mediated cargo transport are governed by guest binding affinity. Using sequential transport across two consecutive membranes, target compounds were isolated from a mixture in a size-selective fashion. The selectivities of both cages thus enabled a two-stage separation process to isolate a single compound from a mixture of physicochemically similar molecules.

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“…The binding properties of coordination cages in solution [5][6][7][8][9][10][11][12][13][14][15][16][17] has been tailored to species ranging from gases [18][19][20][21] to heavy metals 21 , and neutral [22][23][24] and charged compounds [25][26][27][28][29][30] . A cage dissolved in one fluid phase is capable of extracting a guest from another immiscible one, without crossing the phase barrier 31 .…”

mentioning

confidence: 99%

Coordination Cages Transport Molecular Cargoes Across Liquid Membranes

Nguyen

Jd²,

Grommet³

et al. 2021

Preprint

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Chemical purifications are critical processes across many industries, requiring 10 - 15% of humanity’s global energy budget1,2. Coordination cages are able to catch and release guest molecules based upon their size and shape3,4, providing a new technological basis for achieving chemical separation. Here we show that aqueous solutions of FeII4L6 and CoII4L4 cages can be used as liquid membranes. Selective transport of complex hydrocarbons across these membranes enabled the separation of target compounds from mixtures under ambient conditions. The kinetics of cage-mediated cargo transport are governed by guest binding affinity. Using sequential transport across two consecutive membranes, target compounds were isolated from a mixture in a size-selective fashion. The selectivities of both cages thus enabled a two-stage separation process to isolate a single compound from a mixture of physicochemically similar molecules.

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On/off fluorescence emission induced by encapsulation, exchange and reversible encapsulation of a BODIPY-guest in self-assembled organometallic cages

Abstract: A reversible fluorescence turn off/on switch induced by the encapsulation and release of a guest molecule within an organometallic cage was presented.

Cited by 19 publications

References 58 publications

Multistimuli-Responsive Fluorescent Organometallic Assemblies Based on Mesoionic Carbene-Decorated Tetraphenylethene Ligands and Their Applications in Cell Imaging

Multistimuli-Responsive Fluorescent Organometallic Assemblies Based on Mesoionic Carbene-Decorated Tetraphenylethene Ligands and Their Applications in Cell Imaging

Coordination Cages Selectively Transport Molecular Cargoes Across Liquid Membranes

Coordination Cages Transport Molecular Cargoes Across Liquid Membranes

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