Let K = Q(θ) be a number field generated by a complex root θ of a monic irreducible trinomialIn this paper, we deal with the problem of the non-monogenity of K. More precisely, we provide some explicit conditions on a, b, n, and m for which K is not monogenic. As application, we show that there are infinite families of non-monogenic number fields defined by trinomials of degree n = 2 r • 3 k with r and k are positive integers. We also give two infinite families of non-monogenic number fields defined by trinomials of degree 6. Finally, we illustrate our results by giving some examples.