Abstract-This paper presents a realistic and fairly interdisciplinary approach to perform comparative analysis and evaluation of academic performance of two applicable educational packages (modules). Both have considered as diversified instructional methodologies with effective utilization of visual and auditory multisensory (multimedia) teaching for two different topics taught to children with average age about 11 years old. By more details, one of these topics concerned with learning "How to solve long division problem?‖. That has carried out by sequential processes: Divide, Multiply, Subtract, Bring Down, and repeat (if necessary). However, the second is associated with the critical instructional issue of "how to teach/learn reading?" Both adopted modules have carefully designed in order to develop two multimedia educational packages to be applicable for both above adopted topics at children's classrooms. Interestingly, obtained results proved to have significant improved distinction for the applied multisensory methodology (experimental groups) versus the classical one (control groups). That improvement has been clearly observed not only regarding average (mean) values of academic achievement, but also considering coefficient of variation which improvement results in more consistency of the statistical distribution of academic achievement's values. Furthermore, both multisensory designed modules proved to be in well agreement likewise the Artificial Neural Network (ANN) associative memories theory, cognitive multimedia, and classical conditioning.